Curriculum Vitae - Ahi Evran Üniversitesi

Curriculum Vitae - Ahi Evran Üniversitesi

Curriculum Vitae
Adı Soyadı: Aslıhan GÜNEL
Date of Birth: 25.11.1973
Birth Place: Istanbul-TURKEY
Contact information:
Tel:+90 (530) 6146031
e-mail: [email protected]
[email protected]
Research Interests




Gel based and gel free proteomics studies on plant pathogene interactions
Proteomics on neurodegenerative diseases
Bioactive molecules
Enzyme purification and caracterisation and inhibition
EDUCATION:
Degree
BSc
MSc
Ph.D.
University
Marmara University
Marmara University
Marmara University
Chemistry
Biochemistry
Biochemistry
Year
1994
1996
2002
Thesis and Supervisors :
MSc Thesis: “Isolation and purification of soluble proteins in Red Beet III-Fractions
precipitated in 60-65% Ammonium Sulphate saturation”
Supervisor:Prof. Dr. Ayşe OGAN
Doktora
Tezi/S.Yeterlik
Danışman(lar)ı:
Çalışması/Tıpta
Uzmanlık
Tezi
Başlığı
ve
Doktora Tezi: “Isolation of the aromatic L-aminoacid decarboxylase (EC 4.1.1.28) from
the barains of the rats having 6-hydroxy dopamine induced Parkinson Disease and
investigation of the enzyme by two dimensional electrophoresis”
Supervisor:Prof. Dr. Ayşe OGAN Görevler:
Work Experience
Occupation
Place
Year
Associated
Prof. Dr.
Assistant
prof. Dr.
Post-Doc
Post-doc
Assistant
prof. Dr.
Assistant
prof. Dr.
Ahi Evran Üniversity
2014-
Ahi Evran Üniversity
2009-2014
Cereal Research Center, AAFC, CANADA
Middle East Technical University
Sinop University
2011-2012
2005-2011
2007-2009
19th May University
2005-2007
Supervised Thesis:
ÇetinTürk, Merve "Identification of biological molecules playing role in PAMPs
triggered immunity in leaf rust (Pucciniatriticina) disease in wheat by
proteomics approach” Ahi Evran Uniiversity (2013-).
EMİR, Mahmut “Proteome profiling of Dreschlera teres f. maculata isolates
causing net blotch spot form in barley” Ahi Evran Uniiversity (2014-).
TÜRK, M. Rifat “Secretome Profiling of Dreschlera teres f. maculata isolates
causing net blotch spot form in barley” Ahi Evran Uniiversity (2014-).
Özgazi, Neşe “Analysis of the wheat and Blumeria Graminis (powdery mildew)
proteomes during a susceptible host-pathogen interaction”, METU,
Supervisor).
2009. (Co-
Bozhanaj, Kreshnik “The effect of virus induced gene silencing of FAS-associated
factor 1 in Blumeria graminis infected barley” METU, 2009. (Co-Supervisor).
Atıcı, Elif “Detection, cloning, sequencing and transcription level analysis of
Puccinia striiformis f. sp. tritici genes expressed in host plant” METU, 2012. (CoSupervisor).
Dagvadorj, Bayantes “Identification of proteins interacting with tagged-pathogen
effector protein in agro-delivered planta” METU, 2012. (Co-Supervisor).
Projects Involved :
"Proteome Mapping of Pyrenophora teres f. maculata fungi causing Netblotch Disease in
Barley (Supervisor, 2014-2016, TÜBİTAK 3001, project no: 114Z084)
"Identification of biological molecules playing role in PAMPs triggered immunity in leaf
rust (Pucciniatriticina) disease in wheat by proteomics approach” Ahi Evran University
(Supervisor, Ahi Evran University BAP-, 2012-2015)
“Development of Education Substructure of Biochemistry Laboratories for Chemistry and
Biology Departments” (Supervisor, Ahi Evran University -BAP,2012-2013)
“Investigation of Resistance Mechanisms against to Stripe rust in wheat in Proteome
Level by using new generation two dimentional Liquid Chromatography System” (COST109T293 2009-2013) (Consulting of Projects)
“Detection of possible changes in Experimental Epilepsy Model by Proteome Anlysis”
(TUBITAK-) (Researcher, 2005-2008).
”GenPro” State Planning Organisation(Post-Doc and lab management) under supervise of
Prof.Dr. Mahinur AKKAYA at Middle East Technical University in Ankara. 2004-2007.
Marmara University Research Found , Project No: FB No:1,
“Isolation of the aromatic L-aminoacid decarboxylase (EC 4.1.1.28) from the barains of
the rats having 6-hydroxy dopamine induced Parkinson Disease and investigation of the
enzyme by two dimensional electrophoresis” (Resercher)
Marmara University Research Found , Project No: 97-FB-16,
"Identification of Casein Factions by Immunoblotting" Researcher
Marmara University Research Found , Project No 10.
“Determination of Amino Acid Sequences of Medical Plants” Researcher
Fellowships and Awards
TUBITAK “2219 Post-Doc Fellowship” (February -September 2011) AAFC-Cereal
Research Centre-Winnipeg-Canada.
Young Investigator Award in 28th World Epilepsy Congress in Budapes/Hungary June 28July 2 Budapest-Hungary,28th International Epilepsy Congress
Idiopathic Generalized Epılepsies Developmental Aspects; Bridging Basic Science And
Clinical Research ( Fellowship.) 3-6 October 2007, Antalya-Turkey
Educational Course:IGE2007 (Basic Concepts in genetics of Epilepsy :From Phenotyping to
Genetic Investigations) 3 October 2007, Antalya-Turkey
First Placed Degree in Ph.D at Marmara University 2002.
NATO-ASI Fellowship: International School of Structural Biology and Magnetic Resonance.
5th Course: Protein Structure, Dynamics, Genomics and Function- (2001, Erice, Sicily,
ITALY)
First Placed Degree in Summerschool for MSc andPh.D Students: "Protein Purification and
Characterization İzmir 1997
Graduation with 3rd placed degree from Dept. of Chemistry 17.6.1994
Encouragement Award for BSc Students in chemistry Department:Marmara University 1993
Encouragement Award for BSc Students in chemistry Department:Marmara University 1992
Lectures involved
Academic
Year
20142015
Semester
Fall
Fall
20132014
Spring
20112012
Fall
Spring
Lecture
Clinical
Biochemistry(Undergrad.)
Enzymology (Agricultural
Faculty)
Advanced Biochemistry I
(Graduated Students)
Proteomics and
Applications (Graduated
Students)
Credit per week
Theorical Application
3
0
Biochemistry I
(undergrad)
Advanced Biochemistry I
(Graduated Students)
Proteomics and
Applications (Graduated
Students)
Biochemistry II
(Undergrad)
Advanced Biochemistry II
(Graduated Students)
Metabolic pathways
(Graduated Students)
Biochemistry I
(Undergrad)
BiochemistryII
(Undergrad)
Students
4
2
0
6
3
0
3
3
0
3
4
0
36
3
0
1
3
0
1
4
0
35
3
0
2
3
0
2
4
0
23
4
0
23
Publications
A. Publications in International Peer Reviewed Journals
A1.Rampitsch C., Gunel A., Beimcik E., Mauthe W., M“The proteome of monoclonal
antibody-purified haustoria from Puccinia triticina Race-1” Proteomics
15(2015) 13071315...\Desktop\monoclonal ab haustoria.pdf
A2. Şardan M., Sezer S., Günel A., Akkaya M., Tanyeli C., “Synthesis and biological
evaluation of optically active conjugated γ- and δ- lactone derivatives” Bioorganic &
Medicinal Chemistry Letters 22(2012) 5814-5818...\Desktop\bioorganic medicinal
chemistry letter.pdf
A3. Danis,O., Demir, S., Gunel, A., Aker., RG, Gülçebi, M., Onat F., Ogan, A., “Changes
in intracellular protein expression in cortex, thalamus and hippocampus in a genetic rat
model of absence epilepsy” Brain Research Bulletin 84(2011) 381-388...\Desktop\Brain
Resaerch Bulletin.pdf
A4. Kishali, N.H., Doğan, D., Şahin, E., Gunel, A., Kara, Y., Balci, M., “Stereoselective
synthesis of deoxycarbaheptopyranose derivatives: 5a-carba-6-deoxy-α-DL-galacto
heptopyranose and 5a-carba-6-deoxy-α-DL-gulo-heptopyranose” Tetrahedron 67(2011)
1193-1200...\Desktop\Tetrahedron 2011.pdf
A5. Baran, A., GuneL, A., Balci, M., “Synthesis Of Bicyclo[2.2.2]OCTANE-2,3,5,6,7,8
Hexols (Bishomoinositols):New Glycosidase Inhibitors” Journal Of Organic Chemistry
73(2008) 4370-4375. ..\Desktop\JOC 2008.pdf
A6. Günel A.,Aker. R., Onat F., Ogan A., “Alterations in the kinetic activity of aromatic
L-aminoacid decarboxylase and preliminary 2-DE investigation of the brains in the 6OHDA induced Parkinson’s disease model of rat”. Marmara Medical Journal. 16 (2003)
179-187.
A7. Günel, A., .El-Asbahi, A.,Özgazi N., Akkaya, M.S. " Identification of differentially
expressed proteins in wheat after benzothiadiazole treatment Journal of Plant Disase and
Protection 119(2012)182-190...\Desktop\gunel_et_al JPDP.pdf
A8. Maytalman D., Mert Z., Baykal AT., Inan C., Günel A., and Hasançebi S.,, "Proteomic
analysis of early responsive resistance proteins of wheat (Triticum aestivum) to yellow
rust (Puccinia striiformis f. sp. tritici) using ProteomeLab PF2D", Plant omics Journal
(ISI) , 24-35 pp., 2013 ..\Desktop\plantomics2013.pdf
B. Proceedings in International Congress
B1. Rampitsch C., Beimcik E., McCallum B., Fan T, Gunel A., Bakkeren G., Comparative
proteomics of monoclonal-antibody enriched haustoria from three races of Puccinia
triticina. 27th Fungal Genetics Seminar at Asilomar CA
B2.Günel A, Rampitsch C, Beimcik E, Fan T, Akkaya MS, “Purification of Stripe Rust
Haustoria with Monoclonal Antibodies” International Conference Plant Diseases and
Resistant Mechanisms. Viyana-Avusturya S:82. 20-22 Şubat 2013
B3. İnan C, Maytalman D, Mert Z, Baykal AT, Çevik S, Günel A, Arda N, Hasançebi S
“Proteomic approach to investigate wheat resistance response against yellow rust using
ProteomeLab PF2D”. 15th European Congress of Biotechnology, p: S129, 23-26
September 2012, İstanbul (poster)
B4. Demirci YE, İnan C, Mert Z, Baykal AT, Günel A, Korkut ŞV, Hasançebi S “Proteomic
investigation of compatible interaction between wheat and yellow rust” 15th European
Congress of Biotechnology, p: S192, 23-26 September 2012, İstanbul (poster)
B5. Rampitsch C., Beimcik E., McCallum B., Fan T, Gunel A., Bakkeren G., “The
Proteome of Haustoria from Puccinia triticina” 13th International Cereal Rust and
powdery mildew conference, Beijing-CHINA 28 August-01 September 2012.
B6. Aksoy Y, Günel A, Ersoy F, Öztürk İ, Akkaya M, “Hv Rad23 is a negative regülatör of
powdery mildew disease resistance in Barley”
S:96, Beijing-CHINA 28 August-01
September 2012.
B7. Rampitsch C., Gunel A., Beimcik E., Fan T. “The proteome of intracellular feeding
structures purified from the wheat leaf rust pathogen, Puccinia triticina”Tandem MS
WorkShop Lake Louise, CANADA 1-3 December 2011.
B8. Özgazi N, Günel A,, Aydemir Ü, Atıcı E, Akkaya M. S. “Proteome analysis of virulent
and avirulent Blumeria graminis f. sp. hordei inoculated barley” 12th International Cereal
Rusts And Powdery Mildews Conference Antalya-TURKEY 13-16 Ekim 2009(sözel bildiri)
B9.Günel A, Al-Asbahi A, Özgazi N, Akkaya M, “Identification of proteins differentially
expressed upon BTH traetment of Triticum aestivum (wheat)by proteomics Approch”12th
International Cereal Rusts And Powdery Mildews Conference Antalya-TURKEY 13-16 Ekim
2009
B10. Gunel,A, Danis O, Demir S, Ogan A, Aker R, Onat F, Çelebi M “Identification of
differentiated Proteins in GAERS by proteomics approach” 28th ILAE Epilepsy Congress
Budapest-Hungary 28 Haziran-2 Temmuz 2009
B11. Sezer, S., Şardan, M., Özgazi, N., Aydemir, Ü., Günel, A., Akkaya, M., Tanyeli, C.,
“Synthesis Of New Enantiomerically Pure Heteroaryl Substituted Α,Β Unsaturated
Lactones And Evaluatıon Of Antimicrobial And Antioxidant Activity” International
Symposium on Drug Research and Development “From Chemistry to Medicine” DRD 2009
Ankara-Türkiye 4-7 Mayıs 2009
B12. Gunel, A., Ozgazi, N., Akaya, M.S. “Proteome analysis virus induced gene silenced
wheat” International Conference on Proteomics, Luxemburg 22-25 Ekim 2008(sözel
bildiri)
B13. Demir, S., Danış, Ö., Aker, R., Günel, A., İdrizoğlu, M. G., Onat, F., Ogan, A. “ The
profile of The hipocampus, Cortex and Thalamus Proteomes In the Genetıc” IGE2007
Kongresi, Antalya-Türkiye 3-6 Ekim 2007
B14. Gunel, A., El-Asbahi, A., Zeybek A., Akkaya M. “Purification and 2D-PAGE Analysis
of BTH Induced Wheat Proteins“ ProteomLux2006; International Conference on
Proteomics, Luxemburg11-14 Ekim 2006
B15. Danis, O., Demir, S.Aker, R., Gunel, A.), Onat, F. Ogan, A. “Determination of
alterations in protein profiles of brain tissues of experimental epilepsy models by
proteome analysis“ 31. FEBS Kongresi Istanbul Turkiye 24-29 Haziran 2006
B16. Gunel, A., Ogan, A., Onat, F., Aker R. “Alterations in the Kinetic Activity of
Aromatic-L- Amino Acid Decarboxylase and Preliminary 2-DE- Investigation of The Brains
in the 6-OHDA induced Parkinson’s Disease Model of Rat”, Dutch 4th Endo-physico-neuro
workshop Doorwerth-NETHERLAND, 31 Mayıs-3 Haziran 2005
B17. Gencer, Ö., Ogan, A., Günel, A. "Identification of Casein Fractions by
ImmunoblottingTechnique", Birinci Uluslararası Biosciences Days, Antalya-TURKİYE,
Nisan 20-24, 1999.
B18. Ogan, A., Günel, A., Gencer. Ö., Enginün, M. "Purification of Identification Soluble
Proteins of Red Beet Juice I. Molecular Weight and Primary Structure Determination," 35.
IUPAC Kongresi, Istanbul-TURKİYE, Ağustos 14-19, 1995.
C. Publications in National Peer Reviewed Journals
C1. Ogan, A., Karsılayan Kuzu, H., Demir, S., Gencer Önder, Ö., Günel, A., Enginün M.
“Investigation of Red Beet [Beta Vulgaris L.(Subsp. Rapa F. Rubra )] juice proteins for
vitamin B12 binding”. Journal of Faculty of Pharmacy of İstanbul University. 37 (2004)
13.
C2. Ogan, A., Gencer Önder, Ö., Günel, A. “Identification of Human beta Casein on
polyacrlyamide gels electroblotted on to nitorcellulose membranes by N-Terminal
Analysis”. Chimica Acta Turcica. 31(2003) 5.
C3. Ogan, A., Günel, A., Gencer, Ö., Enginün, M. “Purification of soluble proteins of Red
beet juice precipitated by seventy percent ammonium sulfate saturation I. Identification
of fractionII protein” Chimica Acta Turcica, 24 (1996) 199-202.
D. Presentations in National Congress:
D1. Dilara Maytalman, Aslıhan Günel, Yavuz Öztürk, A. Tarık Baykal, Lütfi Çetin, Zafer
Mert Semra Hasançebi. “New generation two dimentional liquid chromatography (2D-LC)
in wheat (Triticum aestivum l.) proteomics studies” Ist National Molecular Biology and
Biotechnology Congress. Antalya-TURKEY October 2010,
D2.Günel A, Özgazi N, Aydemir Ü, Atıcı E, Akkaya MS,”Investigation of host-pathogene
interaction in Blumeria graminis f.sp. hordei inoculated susceptible and resistant barley
cultivars by proteomics approach” 21st National Biochemistry Congress İstanbul 2009
D3. Cihan İnan, Dilara Maytalman, Zafer Mert, Ahmet Tarık Baykal, Sertan Çevik, Aslıhan
Günel, Nazlı Arda, Semra Hasançebi. “Comperative proteomics analysis in wheat;
determination of proteins in plant-pathogene interactions” IInd National Molecular
Biology and Biotechnology Congress. 15-18 November 2012, Antalya- TURKEY
D4. Yahya Emin Demirci, Cihan İnan, Zafer Mert, Ahmet Tarık Baykal, Aslıhan Günel,
Şenay Vural Korkut, Semra Hasançebi. Investigation of development of stripe rust
infection in proteome level in susceptible local wheat cultivar (Triticum aestivum) Seri82.
IInd National Molecular Biology and Biotechnology Congress. 15-18 November 2012,
Antalya- TURKEY
D5.Günel, A., Danış, Ö., Demir, S., Ogan, A., Aker, R., Onat, F., Gülçebi, M.
“Identification of Differentiated Proteins in GAERS by Proteomics Approach” 8th National
Neurosiencess Congress Bolu-Turkey 18-22 April 2009. Turkish Journal of Neurology
15(Ek.1) (2009) 145-146.
D6. Günel, A., Özgazi, N., Ünver, T., Akaya, M. S. “Identification of differentiated
proteins i,n Rad 6 gene silenced wheat by 2D-PAGE and Mass Analyses” XVth National
Biotechnology Congress Antalya- TURKEY 28-31 October 2007.
D7. Ogan, A., Demır, S., Karsılayan Kuzu, H., Gencer, Ö., Günel, A., Enginün, M., “
Elucidatiın of Vitamin B12 binding Proteins in Red Beet Juice”, XVIIth National
Biochemistry Congress Ankara-TURKEY, 24-27 June 2002.
D8. Günel, A. " Separation and Purification of the Soluble Proteins of Red Beet Juice III,
60-65%Ammonium Sulfate Saturation Proteins”, XI. Ulusal Kimya Kongresi, VanTURKİYE, Haziran 16-20, 1997.
E. Other Scientific Activities :
Turkish Journal of Chemistry Reviewer. Mayıs 2009
Plant Omics Journal Reviewer March 2013 ve August 2014
Aslıhan Günel, Ş. Betül Sopacı Biochemistry Laboratuar Manual
Seminers
“Proteomics Studies in Disease-Resistance
“TÜBITAK-MAM “ (Invited)
Mechanisns
in
Wheat”
(17.11.2008)
“Proteomics Sudies in Wheat” (27.01.2007) ) Yıldız Teknichal University,Department of
olecular Biolog and Genetics Biyoloji Bölümü (Invited).
Proteomics and Applications (18.05.04) “Marmara University, Medicl School, Deparrtment
of Pharmacology and Clinical Pharmacology (Invited).