Özgeçmiş - İstanbul Arel Üniversitesi

ÖZGEÇMİŞ
1.
Adı Soyadı: Mehmet Özbil
2.
Doğum Tarihi: 19.09.1984
3.
Unvanı: Doktor
4.
Öğrenim Durumu: Doktora
Derece
5.
Alan
Üniversite
Yıl
Lisans
Kimya
İstanbul Teknik Üniversitesi
2007
Y. Lisans
Kimya
University of Miami
2013
Doktora
Kimya
University of Miami
2013
Akademik Ünvanlar:
Yardımcı Doçentlik Tarihi : 01.09.2015
Doçentlik Tarihi
:
Profesörlük Tarihi
:
6.
Yönetilen Yüksek Lisans ve Doktora Tezleri
6.1. Yüksek Lisans Tezleri
6.2. Doktora Tezleri
7.
Yayınlar
7.1. Uluslararası hakemli dergilerde yayınlanan makaleler (SCI & SSCI & Arts and Humanities)
1. Block, E., Jang, S., Matsunami, H., Batista, V.S., Dethier, B., Ertem. M.Z., Gundala, S.,
Jiang, H., Li, S., Li, Z., Lodge, S.N., Ozbil, M., Pan, Y., Penalba, S.F., Sekharan, S., and
Zhuang, H. “Implausibility of the vibrational theory of olfaction”. Proceedings of National
Academy of Sciences,USA, 112, E2766–E2774, 2015.
2. Derrick, J.S., Kerr, R.A., Nam, Y., Oh, S.B., Lee, H.J., Earnest, K.G., Suh, N., Peck,
K.L., Ozbil, M., Korshavn, K.J., Ramamoorthy, A., Prabhakar, R., Merino, E.J., Shearer,
J., Lee, J-Y., Ruotolo, B.T., and Lim, M.H. “A redox-active, compact tool for the
crosslinking of amyloidogenic peptides into nontoxic, off-pathway aggregates: in vitro
and in vivo efficacy and molecular mechanisms”. Journal of American Chemical Society,
137(46), 14785-14797, 2015.
3. Song, E.S., Ozbil, M., Zhang, T., Sheetz, M., Lee, D., Tran, D., Li, S., Prabhakar, R.,
Hersh, L.B., and Rodgers, D.W. “An Extended Polyanion Activation Surface in Insulin
Degrading Enzyme”. PLOS One, 10(7) : e0133114., 2015.
4. Zhang, T., Ozbil, M., Barman, A., Paul, T.J., Bora, R.B., and Prabhakar, R. “Theoretical
Insights into the Functioning of Metallopeptidases and Their Synthetic Analogues”.
Accounts of Chemical Research, 48(2), 192-200, 2015.
1
5. Sekharan, S., Ozbil, M., Ertem, M.Z., Ten, N., Pan, Y., Zhang, R., Zhuang, H., Block, E.,
Matsunami, H., and Batista, V.S. “An Interhelical Lock Mechanism For Olfaction”.
Angewandte Chemie International Edition, yollandı, 2015.
6. Cook, N.P., Ozbil, M., Katsampes, C., Prabhakar, R., and Martí, A.A. “Unraveling the
photoluminescence response of light-switching ruthenium (II) complexes bound to amyloidβ”.
Journal of American Chemical Society, 135: 10810–10816, 2013. (C&EN NEWS
dergisinde de atifta bulunuldu, 90, 21, 27, July 22 Issue, 2013).
7. Liu, Y., Mukherjee, A., Nahumi, N., Ozbil, M., Brown, D., Angeles-Boza, A.M., Dooley,
D.M., Prabhakar, R., and Roth, J.P. “Experimental and Computational Evidence of MetalO2 Activation in a Copper Amine Oxidase”. Journal of Physical Chemistry B, 117:218–229,
2013.
8. Ozbil, M., Barman, A., Bora, R.P., and Prabhakar, R. “Perspective: Computational Insights
into Dynamics of Protein Aggregation and Enzyme-Substrate Interactions”. Journal of
Physical Chemistry Letters, 3, 3460-3469, 2012.
9. Kurouski, D., Washington, J., Ozbil, M., Prabhakar, R., Shekhtman, A., and Lednev, I.,
“Disulfide Bridges Remain Intact While Native Insulin Converts into Amyloid Fibrils”. PLoS
ONE, 7 : e36989, 2012.
10. Zhu, X., Barman, A., Ozbil, M., Zhang, T., Li, S. and Prabhakar, R., “Mechanism of Peptide
Hydrolysis by Co-catalytic Metal Centers Containing Leucine Aminopeptidase Enzyme: A
DFT Approach”. Journal of Biological Inorganic Chemistry, 17, 209-222, 2011.
11. Bora, R.P., Barman, A., Zhu, X., Ozbil, M., and Prabhakar, R., “Which One Among Aspartyl
Protease, Metallopeptidase, and Artificial Metallopeptidase is the Most Efficient Catalyst in
Peptide Hydrolysis?”. Journal of Physical Chemistry B, 114,10860-10875, 2010.
12. Bora, R.P., Ozbil, M., and Prabhakar, R., “Elucidation of Insulin Degrading Enzyme
Catalyzed Site Specific Hydrolytic Cleavage of Amyloid β -Peptide: A Comparative DFT
Study”. Journal of Biological Inorganic Chemistry, 15, 485-495, 2010.
7.2. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan bildiriler
1. Ozbil, M. and Prabhakar, R. “Mechanisms of Stimulation of Insulin Degrading Enzyme
(IDE) and Substrate Specificity of Neprilysin (NEP)” ACS National Meeting, New Orleans,
LA, 7-11 Nisan, 2013. (Chairs` Prime Choices Section`a seçilmiştir.)
2. Ozbil, M. and Prabhakar, R., “Investigating The Activation of Insulin Degrading Enzyme
(IDE) and Selectivity of Neprilysin (NEP)” FAME-ACS Florida Section Meeting, Tampa, FL,
17-20 Mayıs, 2012.
3. Ozbil, M. and Prabhakar, R., “Investigating The Peptide Bond Hydrolysis by Neprilysin
(NEP)” FAME-ACS Florida Section Meeting, Tampa, FL, 15-18 Mayıs, 2011.
2
4. Ozbil, M. and Prabhakar, R., “Computational Study of Neprilysin (NEP) and The Full Length
Alzheimer`s Amyloid Beta (Aβ)” FAME-ACS Florida Section Meeting, Tampa, FL, 13-16
Mayıs, 2010.
8.
Projeler
1. TÜBİTAK-2232 Yurda Dönüş Araştırma Burs Programı. “İnfluenza A Virüsü M2 Proteinin
İşleyiş ve İnhibisyonunun Bilgisayarlı Hesaplamalarla İncelenmesi”. Yürütücü. İstanbul Arel
Üniversitesi, Moleküler Biyoloji ve Genetik Bölümü, İstanbul, Türkiye. 2015-2017.
2. “Exploring the mechanism of human olfactory receptor and the allosteric regulation of
indole-3-glycerol-phosphate synthase (IGPS) by small activator molecules”, Araştırmacı.
Department of Chemistry, Yale University, USA. 2014-2015.
3
9.
“Integrated Theoretical and Computational Approaches to Study Hydrolysis and
Aggregation of Biomolecules”, Araştırmacı. Department of Chemistry, University of Miami,
USA, 2008-2013.
İdari Görevler
1. İstanbul Arel Üniversitesi
Moleküler Biyoloji ve Genetik Bölüm Başkan Yardım ısı
2015-
10. Bilimsel ve Mesleki Kuruluşlara Üyelikler
11.
1. Türkiye Kimya Derneği
2015-
2. American Chemical Society
2013-
Ödüller
1. Dean`s Summer Research Fellowship with the project entitled, “The Mechanism and
Structure-Function Relationship of Zn Metalloproteinase”, College of Arts and Sciences,
University of Miami, 2012.
2. Perpetual Best Graduate Teaching Assistant Award, Department of Chemistry, University of
Miami, 2011.
3. Perpetual Best Graduate Teaching Assistant Award, Department of Chemistry, University of
Miami, 2010.
4. Best Graduate Teaching Assistant Award, Department of Chemistry, University of Miami,
2009.
12.
Son iki yılda verdiğiniz lisans ve lisansüstü düzeydeki dersler için aşağıdaki tabloyu doldurunuz.
Akademik
Yıl
Dönem
Dersin Adı
General Chemistry-1
2015
Güz
Organic Chemistry-1
Haftalık Saati
Teorik Uygulama
3
2
3
Protein Folding/Misfolding
13.
25
3
Biochemistry Lab-1
3
Öğrenci
Sayısı
22
14
4
İş ve Araştırma Deneyimi
1. Postdoctoral Associate, Yale University, CT, USA.
2014-2015
3