Docent Doktor H. NADIR ÇIRAY, PhD Histolog ve Embriyolog Egitim

Docent Doktor H. NADIR ÇIRAY, PhD Histolog ve Embriyolog Egitim

Docent Doktor H. NADIR ÇIRAY, PhD
Histolog ve Embriyolog
Egitim ve Akademik Dereceler
Docent
2004
Yardimci Docent
2000, Kadir Has Universitesi, Istanbul
Bolum Baskani
2000, Kadir Has Universitesi Tip Fakultesi,
Histoloji ve Embriyoloji Bolumu (kurucu)
Gozlemci arastirmaci
2000 (3 ay), Samuel Lunenfeld Arastirma Enstitusu,
Toronto, Kanada
(Destek Isvec Ulusal Arastirma Fonundan karsilanmistir)
Doktora
1996, Uppsala Universitesi Tip Fakultesi, Uppsala, Isvec
Tez basligi:
Gap junctions in human myometrium; structural and functional
aspects (Acta Universitatis Upsaliensis ISBN-10: 9155437753)
Yoneten:
Histoloji ve Embriyoloji Uzmani
Tez basligi:
Prof. Dr. Ulf Ulmsten
1990, Ankara Universitesi Tip Fakultesi
Ultrastructure of human myometrium during pregnancy and
labor
Yoneten:
Tip Doktoru
H. Nadir Ciray, MD., PhD
July 2012
Prof. Dr. Meral Tekelioglu
1987, Ankara Universitesi Tip Fakultesi
Mesleki Sertifikalar
Senyor Embriyolog, ESHRE, 2008Mesleki Gecmis (Tibbi)

Embriyoloji Laboratuarlari Direktoru (Aralik 1999-Mayis 2012)
Bahceci Saglik Grubu IVF Laboratuarlari
2011 embriyo transferi siklus sayisi: 7418 taze, 1850 cozdurme
Toplam calisan embriyoloji laboratuari/klinigi=6

Klinik Embriyolog (1997-1998)
International Hospital Istanbul

Embriyolog
(1996-1997)
Uppsala Universitesi, Uppsala, Isvec
Mesleki Gecmis (Idari ve Isletme)

Bilimsel Direktor ve Hissedar (2009-2012)
Gonagen Sirketi
Bahceci Grubunun tibbi malzeme destekcisi. Temsilcisi oldugu IVF ile ilgili urunleri Bahceci
Grubunun bulundugu ulkelerde dagitir. Exclusive distributorlukler arasinda Irvine Scientific,
UniSense vb. sayilabilir.
Sorumluluklar; IVF ile iliskili yeni urunlerin saptanmasi, firmalarla temas kurulmasi,
distributorluk olanaklarinin tespiti ve saglanmasi, firmadaki pazarlama elemanlarinin egitimi

Bahceci Fulya Klinigi Isletme Muduru (2011-2012)
Grubun Fulya’da bulunan ana merkezinin isletmesi
Sorumluluklar; Personelin idaresi (yaklasik 50 kisi), klinigin gunluk rutininin idamesi, yasal
raporlama prosedurleri
H. Nadir Ciray, MD., PhD
July 2012
BIBLIOGRAFI
Hakemli Uluslararasi Bilimsel Dergiler
1. Ciray HN, Aksoy T, Goktas C, Ozturk B, Bahceci M. Time-lapse evaluation of human
embryo development in single versus sequential culture media-a sibling oocyte study.
Journal of Assisted Reproduction and Genetics. 2012 Jun 20. [Epub ahead of print]
2. Mesut N, Ciray HN, Mesut A, Aksoy T, Bahceci M. Cryopreservation of blastocysts is
the most feasible strategy in good responder patients. Fertility and Sterility. 2011;96:
1121-1125.
3. Bakircioglu ME, Ulug U, Erden HF, Tosun S, Bayram A, Ciray N, Bahceci M.
Klinefelter syndrome: does it confer a bad prognosis in treatment of nonobstructive
azoospermia? Fertility and Sterility. 2011;95: 1696-1699.
4. Uyar A, Bener A, Ciray HN, Bahceci M. Physician experience in performing embryo
transfers may affect outcome. Fertility Sterility. 2011; 95:1860-1862.
5. Coban O, Hacifazlioglu O, Ciray HN, Ulug U, Tekin HI, Bahceci M. Birth after 12
hours of oocyte refrigeration. Fertility Sterility. 2010; 94:2769, e5-7.
6. Sismanoglu A, Tekin HI, Erden HF, Ciray NH, Ulug U, Bahceci M. Ovulation triggering
with GnRH agonist vs. hCG in the same egg donor population undergoing donor oocyte
cycles with GnRH antagonist: a prospective randomized cross-over trial. Journal of
Assisted Reproduction and Genetics. 2009; 26:251-256.
7. Uyar A, Bener A, Ciray H, Bahceci M. A frequency based encoding technique for
transformation of categorical variables in mixed IVF dataset. Conference Proceedings
IEEE Engineering Medicine Biology Society. 2009; 1:6214-6217.
8. Bahçeci M, Ulug U, Erden HF, Tosun S, Ciray N. Frozen-thawed cleavage-stage embryo
transfer cycles after previous GnRH agonist or antagonist stimulation. Reproductive
Biomedicine Online. 2009; 18:67-72.
9. Çıray HN, Aksoy T, Yaramanci K, Karayaka I, Bahçeci M. In vitro culture under
physiological oxygen concentration improves blastocyst yield and quality: a prospective
randomized survey on sibling oocytes. Fertility Sterility. 2009; 91 (4suppl): 1459-1461.
10. Çıray HN, Coban O, Bayram A, Kizilkanat A, Bahceci M. Preliminary study of embryo
development following assessment of male and female gametes. Reproductive
Biomedicine Online. 2008; 16: 875-880.
H. Nadir Ciray, MD., PhD
July 2012
11. Bakırcıoğlu ME, Erden HF, Çıray HN, Bayazit N, Bahçeci M. Gonadotropin therapy in
combination with ICSI in men with hypogonadotrophic hypogonadism. Reproductive
Biomedicine Online. 2007; 15: 156-160.
12. Çıray HN. Even early cleavage and day 2 embryo score. Reproductive Biomedicine
Online. 2007; 14(5):666; author reply 666.
13. Çıray HN, Tosun S, Hacifazlioglu O, Mesut A, Bahçeci M. Prolonged duration of
transfer does not affect outcome in cycles with good embryo quality. Fertility and
Sterility. 2007; 87: 1218-1221.
14. Bakırcıoğlu ME, Erden HF, Kaplancan T, Çıray HN, Bener F, Bahçeci M. Aging may
adversely affect testicular sperm recovery in patients with Klinefelter’s syndrome.
Urology. 2006; 68: 1082-1086.
15. Çıray HN, Uluğ U, Tosun S, Erden HF, Bahçeci M. Outcome of 1114 ICSI-ET cycles
of women 40 years of age and over. Reproductive BioMedicine Online. 2006; 13: 516522.
16. Bahçeci M, Uluğ U, Çıray HN, Akman MA, Erden HF. The efficiency of changing
embryo transfer time from day 3 to day 2 among women with poor ovarian response: a
prospective randomized trial. Fertility and Sterility. 2006; 86: 81-85.
17. Çıray HN, Karagenç L, Uluğ U, Bener F, Bahçeci M. Early cleavage morphology affects
quality and implantation potential of day 3 embryos. Fertility and Sterility. 2006; 85: 358365.
18. Ciray HN, L Karagenc, F Bener, U Uluǧ, M Bahçeci. Reply: Interpretations of
multinucleation—is it ever normal? Fertility and Sterility. 2005;86: 495-495
19. Çıray HN, Karagenç L, Uluğ U, Bener F, Bahçeci M. Early cleavage and day 2
mononucleation are correlated to yield embryos with high implantation potential in
intracytoplasmic injection cycles. Fertility and Sterility. 2005; 84: 1411-1416.
20. Bahçeci M, Çıray HN, Karagenç L, Uluğ U, Bener F. Effect of oxygen concentration
during the incubation of embryos of women undergoing ICSI and embryo transfer: a
prospective randomized study. Reproductive BioMedicine Online. 2005; 11: 438-443.
21. Çıray HN, Bener F, Karagenç L, Uluğ U, Bahçeci M. Impact of assisted hatching on
ART outcome in women with endometriosis. Human Reproduction. 2005; 20: 25462549.
22. Uluğ U, Bener F, Karagenç L, Çıray HN, Bahçeci M. Outcomes in couples undergoing
ICSI: comparison between fresh and frozen-thawed surgically retrieved spermatozoa.
International Journal of Andrology. 2005; 28: 343-348.
H. Nadir Ciray, MD., PhD
July 2012
23. Ulug U, Ciray NH, Tuzlali P, Bahceci M. Partial hydatidiform mole following the
transfer of single frozen-thawed embryo subsequent to ICSI. Reproductive Biomedicine
Online. 2004; 9: 442-446.
24. Karagenc L, Sertkaya Z, Ciray N, Ulug U, Bahceci M. Impact of oxygen concentration
on embryonic development of mouse zygotes. Reproductive Biomedicine Online. 2004;
9: 409-417.
25. Ciray HN, Ulug U, Bahceci M. Transfer of early-cleaved embryos increases implantation
rate in patients undergoing ovarian stimulation and ICSI-embryo transfer. Reproductive
Biomedicine Online. 2004; 8: 219-223.
26. Ciray HN, Fu X, Olovsson M, Ahlsen G, Shuman C, Lindblom B, Ulmsten U. Presence
and localization of connexins 43 and 26 in cell cultures derived from myometrial tissues
from nonpregnant and pregnant women and from leiomyomas. American Journal of
Obstetrics and Gynecology. 2000; 182: 926-930.
27. Fu X, Liu YJ, Ciray N, Olovsson M, Ulmsten U, Gylfe E. Oxytocin-induced oscillations
of cytoplasmic Ca2+ in human myometrial cells. Acta Obstetricia et Gynecologica
Scandinavica. 2000; 79: 174-179.
28. Ciray HN, Backstrom T, Ulmsten U. Ineffectiveness of oxytocin on intercellular
communication between term pregnant human myometrial cells before labor. American
Journal of Obstetrics and Gynecology. 1998; 178: 855-861.
29. Ciray HN, Backstrom T, Ulmsten U, Roomans GM. Steroid hormone effects on
intercellular communication between term pregnant human myometrial cells before labor.
Biology of Reproduction. 1996; 55: 379-385.
30. Ciray HN, Guner H, Hakansson H, Tekelioglu M, Roomans GM, Ulmsten U.
Morphometric analysis of gap junctions in nonpregnant and term pregnant human
myometrium. Acta Obstetricia et Gynecologica Scandinavica. 1995; 74: 497-504.
31. Ciray HN, Persson BE, Roomans GM, Ulmsten U. Dye-coupling between term
pregnant human myometrial cells before labor:carboxyfluorescein versus lucifer yellow.
Cell Biology International. 1995; 19: 609-617.
32. Ciray HN, Persson BE, Backstrom T, Roomans GM, Ulmsten U. Direct intracellular
injections for studying human myometrial gap junctions prior to labor. Acta Obstetricia et
Gynecologica Scandinavica. 1994; 73: 97-102.
33. Roomans GM, Kilarski WM, Ciray N, Persson BE, Backstrom T, Ulmsten U. Structural
and functional studies of gap junctions in human myometrium. European Journal of
Morphology. 1993; 31: 55-59.
H. Nadir Ciray, MD., PhD
July 2012
Abstraktlar
1. H.N. Ciray, T. Aksoy, C. Goktas, B. Ozturk, M. Bahceci. Time-lapse evaluation of
human embryo development in single versus sequential culture media in a sibling oocyte
study. Human Reproduction 27 (Supp1): i105, 2012.
2. M. Serdarogullari, H.N. Ciray, S. Yayla, A. Bayram, M. Bahceci. Female offsprings have
an advanced mitotic cell cycle starting from the initial cleavage. Human Reproduction 27
(Supp1): i42, 2012.
3. A. Bayram, H.N. Ciray, O. Sahin, O. Okutman-Emonts, M. Bahceci. Comparison of
morphokinetic parameters between euploid and aneuploid embryos by time-lapse
monitoring. Human Reproduction 27 (Supp1): i104, 2012.
4. N Mesut, H.N. Ciray, A. Mesut, A. Isler, M. Bahceci. Thaw-transfers of blastocysts
cryopreserved between days five to seven: a comparison of clinical outcomes. Human
Reproduction 27 (Supp1): i174, 2012.
5. O Okutman-Emonts, M Gultomruk, T Aksoy, C Goktas, HN Ciray, M Bahceci.
Combination of biopsy and cryopreservation on cleavage-stage human embryos.
Reproductive BioMedicine Online 24, S47, 2012.
6. Swain JE, Angle M, Ciray N, Liebermann J, Pool T. A commercially available dualbuffered IVF handling medium containing HEPES and MOPS maintains stable pH and
supports human sperm survival, normal fertilization following ICSI and embryo
development. 16th World Congress on In Vitro Fertilization, Tokyo, Japan, 2011.
7. A Bayram, U Ulug, E Bakircioglu, N Ciray, O Sahin, M Bahceci. Comparison of
pregnancy and implantation rates of frozen-thawed embryos fertilized with fresh or
frozen-thawed testicular sperm and fresh ejaculated sperm of normospermic and
oligospermic patients. Fertility and Sterility 96 (3), S208-S208, 2011.
8. A Uyar, A Bener, HN Ciray, M Bahceci. Bayesian Networks for Predicting IVF
Blastocyst Development. International Conference on Pattern Recognition, 2772-2775,
2010.
9. A Uyar, A Bener, HN Ciray, M Bahceci. Prediction of IVF blastocyst development using
Bayesian networks, 7th Turkish Medical Informatics Conference, (TURKMIA 2010), 1417 October 2010, Cyprus. (Best paper award)
10. O Okutman-Emonts, HN Ciray, M Bahçe, T Aksoy, M Bahceci. Aggressive ovarian
stimulation may affect IVF outcome after PGD for reciprocal translocation carriers.
Reproductive BioMedicine Online 20; S30, 2010.
H. Nadir Ciray, MD., PhD
July 2012
11. A Uyar, A Bener, HN Ciray, M Bahceci. ROC Based Evaluation and Comparison of
Classifiers for IVF Implantation Prediction Electronic healthcare: second international
ICST conference, eHealth, 2009.
12. A Uyar, A Bener, HN Ciray, M Bahceci. Handling the Imbalance Problem of IVF
Implantation Prediction. IAENG International Journal of Computer Science 37, 164-170,
2010.
13. A Uyar, A Bener, HN Ciray, M Bahceci. A frequency based encoding technique for
transformation of categorical variables in mixed IVF dataset. Engineering in Medicine
and Biology Society. EMBC 2009.
14. A Uyar, A Bener, HN Ciray, M Bahçeci. Adjusting decision threshold in Naive Bayes
based IVF embryo selection. Biomedical Engineering Meeting, 2009.
15. A Uyar, A Bener, HN Ciray, M Bahceci. Predicting Implantation Outcome from
Imbalanced IVF Dataset. Proceedings of the World Congress on Engineering and
Computer Science, San Fransisco, 2009 (Best Paper Award).
16. A Uyar, HN Ciray, A Bener, M Bahceci. 3P: Personalized pregnancy prediction in IVF
treatment process. Electronic Healthcare, 58-65, 2009.
17. U Ulug, NH Ciray, HF Erden, SB Tosun, M Bahceci. Outcome of ICSI cycles with
single oocyte retrieval. Does ovarian stimulation with gonadotropins have any impact?
Fertility and Sterility 90; S262-S262, 2008.
18. ME Bakircioglu, T Kaplancan, H Erden, U Ulug, N Ciray, M Bahceci. The combination
of gonadotrophin therapy and intracytoplasmic sperm injection in the treatment of male
hypogonadotrophic hypogonadism. Fertility and Sterility 90, S312-S312, 2008.
19. ME Bakircioglu, T Kaplancan, HF Erden, N Ciray, U Ulug, M Bahceci. Comparison of
intracytoplasmic sperm injection outcomes in patients with nonobstructive azoospermia,
cryptozoospermia and oligozoospermia. Fertility and Sterility 90; S314-S314, 2008.
20. ME Bakircioglu, HF Erden, N Bayazit, N Ciray, M Bahceci. Microdissection testicular
sperm extraction outcomes in different etiological patterns of nonobstructive
azoospermia. Fertility and Sterility 88; S391-S392, 2007.
21. U Ulug, N Ciray, S Tosun, M Bahceci. The impact of testicular spermatozoa for ICSI on
the outcome of cryopresrved-thawed embryo transfers. Fertility and Sterility 86; S161S161, 2006.
22. ME Bakircioglu, H Erden, MA Akman, N Bayazıt, N Ciray, M Bahceci. Comparison of
Intracytoplasmic Sperm Injection Outcomes in Patients With Cryptozoospermia and
Severe Oligozoospermia. Fertility and Sterility 84; S221-S221, 2005.
H. Nadir Ciray, MD., PhD
July 2012
23. MA Akman, HF Erden, N Ciray, M Bahceci. A Cocktail of GnRH Agonist and Urinary
hCG to Trigger LH Surge in GnRH Antagonist-IVF Cycles Yields Higher Pregnancy
Rates. Fertility and Sterility 84; S162-S162, 2005.
24. HF Erden, MA Akman, N Ciray, M Bahceci. The Results of the Fresh and Frozen Thaw
Embryo Transfer Cycles of PCOS Patients in Which GnRH Antagonists Were Used
Together With GnRH Agonists for LH Surge. Fertility and Sterility 84; S164-S164, 2005.
25. T Camlibel, AK Kolankaya, B Sarikamis, M Karacan, E Enginsu, N Ciray. Coasting: A
Safe Way to Prevent Hyperstimulation in IVF and ICSI Cycles. Fertility and Sterility 70,
1998.
Kitap ve Kitap Bolumleri
Çıray HN (2011)
Yardimla Ureme Teknikleri: embriyologun gozuyle, ‘Ureme Endokronoljisinde Teknikler ve
Cerrahi Tedaviler’. Gulekli B (ed.) ISBN 978-605-355-020-4
Çıray HN (2007)
Embriyo secim kriterleri; ‘IVF Laboratuar Teknikleri; Guncel uygulamalar ve yaklasimlar’.
Delilbasi L (ed.) ISBN 978-975-277-169-7
Çıray HN (2003)
IVF Laboratuarinda Pratik Yaklasimlar. ISBN 975-288-395-8
Davetli Uluslararasi Kurs Konusmasi
2012 ESHRE Pre-Congress Embryology Course
Sunum Basligi: Development of Culture Media-Impact on Embryo Viability
Uluslararasi Firmalard Bilimsel Danismanlik
Irvine Scientific, Santa Ana, CA-2010/2011
H. Nadir Ciray, MD., PhD
July 2012
Uluslararasi Editorluk ve Bilimsel Hakemlik Gorevleri
Editorial Board
Journal of Clinical Embryology, 2012Bilimsel Hakemlik
Journal of Clinical Embryology, 2012Journal of Assisted Reproduction and Genetics, 2011Human Reproduction, 2009- (best reviewer 2011)
Fertility and Sterility, 2006Reproductive BioMedicine Online, 2007Reproductive Biology and Endocrinology, 2008Mesleki Uyelikler
ESHRE (active)- European Society of Human Reproduction and Embryology
Turkish Clinical Embryology Society (founder)
ALPHA- Society of Scientists in Reproductive Medicine
SSR- Society for the Study of Reproduction
Egitim Tecrubeleri
Kadir Has Universitesi Tip Fakultesi Histoloji ve Embriyoloji Bolumu (1999-2000)
Ankara Universitesi Tip Fakultesi Histoloji ve Embriyoloji Bolumu (1988-1990)
Doktora Yoneticiligi
Asli Uyar, Bogazici Universitesi Bilgisayar Muhendisligi Bolumu
-Application of Machine Learning Methods to Prediction of IVF Outcome
Arastirma Fonlari

TUBITAK
1501 Endustri Destek Programi (2010)
3100035 Proje Numarasi- Whole Genome Amplification from a single cell and scanning of
chromosomal aneuploidies with array

TUBITAK
1507 Orta Olcekli Endustri Destek Programi (2011)
10059 Proje Numarasi- Assessment and Quantification of oocyte competence concomitant to
ICSI
H. Nadir Ciray, MD., PhD
July 2012
Kisisel
Dogum Londra, Ingiltere, 1963
Evli ve bir cocuklu
H. Nadir Ciray, MD., PhD
July 2012