İletişim - e

RSNA-ECR Özel Sayısı
yöntemleri aktif olarak araştırılsa da
halihazırda psödo integra CC/C
oranına bağlı kalmak çok daha
güvenilir oluyor.
Kesin bir şekilde hesaplandğında
CC/C oranı, gözlemlenebilir
spektroskopik verilerin özünü,
herhangi bir görüntü üzerinde
gösterilebilen tek bir niceliğe
dönüştürüyor (Şekil 6), bu sayede
radyolojik raporlama alanında kilit
verileri, okunabilir basit bir formatta
birleştiriyor.
İyi huylu ve tümörlü dokulara ait söz
konusu oranların (syngo.via ilavesine
benzer bir şekilde hesaplanan)
yayınlanmış değerleri Tablo 1’de
listeleniyor.
Referanslar
1 Siegel R, Naishadham D, Jemal A. Cancer
statistics, 2012. CA Cancer J Clin 2012;
62(1):10-29.
2 Hoeks CMA, Barentsz JO, Hambrock T,
Yakar D, Somford DM, Heijmink SWTPJ,
Scheenen TWJ, Vos PC, Huisman H, van
Oort IM, Witjes JA, Heerschap A, Fütterer
JJ. Prostate Cancer: Multiparametric MR
Imaging for Detection, Localization, and
Staging. Radiology 2011; 261: 46 –66.
3 Heerschap A, Jager GJ, van der Graaf M,
Barentsz JO, Ruijs SH. Proton MR
spectroscopy of the normal human
prostate with an endorectal coil and a
double spin-echo pulse sequence.
Magn Reson Med 1997;37(2):204-213.
4 Kurhanewicz J, Vigneron DB, Hricak H,
Parivar F, Nelson SJ, Shinohara K, Carroll
PR. Prostate cancer: metabolic response
to cryosurgery as detected with 3D H-1
MR spectroscopic imaging. Radiology
1996;200(2):489-496.
5 Kurhanewicz J, Vigneron DB, Nelson SJ,
Hricak H, MacDonald JM, Konety B,
Narayan P. Citrate as an in vivo marker
to discriminate prostate cancer from
benign prostatic hyperplasia and normal
prostate peripheral zone: detection via
localized proton spectroscopy. Urology
1995;45(3):459-466.
6 Glunde K, Bhujwalla ZM, Ronen SM.
Choline metabolism in malignant
transformation. Nat Rev Cancer;11(12):
835-848.
7 Costello LC, Franklin RB. Novel role of
zinc in the regulation of prostate citrate
metabolism and its implications in
prostate cancer. The Prostate 1998;
35(4):285-296.
8 Giskeodegard GF, Bertilsson H, Selnaes
KM, Wright AJ, Bathen TF, Viset T,
Halgunset J, Angelsen A, Gribbestad IS,
Tessem MB. Spermine and citrate as
metabolic biomarkers for assessing
prostate cancer aggressiveness. PloS
one;8(4):e62375.
9 Scheenen TW, Klomp DW, Roll SA,
Futterer JJ, Barentsz JO, Heerschap A.
Fast acquisition-weighted threedimensional proton MR spectroscopic
imaging of the human prostate. Magn
Reson Med 2004;52(1):80-88.
10 Scheenen TW, Gambarota G, Weiland E,
Klomp DW, Futterer JJ, Barentsz JO,
Heerschap A. Optimal timing for in vivo
1
H-MR spectroscopic imaging of the
human prostate at 3T. Magn Reson Med
2005;53(6):1268-1274.
11 Shukla-Dave A, Hricak H, Moskowitz C,
Ishill N, Akin O, Kuroiwa K, Spector J,
Kumar M, Reuter VE, Koutcher JA, Zakian
KL. Detection of prostate cancer with
MR spectroscopic imaging: an expanded
paradigm incorporating polyamines.
Radiology 2007;245(2):499-506.
12 Garcia-Martin ML, Adrados M, Ortega MP,
Fernandez Gonzalez I, Lopez-Larrubia P,
Viano J, Garcia-Segura JM. Quantitative
(1) H MR spectroscopic imaging of the
prostate gland using LCModel and a
dedicated basis-set: correlation with
histologic findings. Magn Reson Med;
65(2):329-339.
13 Heerschap A, Jager GJ, van der Graaf M,
Barentsz JO, de la Rosette JJ,
Oosterhof GO, Ruijter ET, Ruijs SH.
In vivo proton MR spectroscopy reveals
altered metabolite content in malignant
prostate tissue. Anticancer research
1997; 17(3A): 1455-1460.
14 Jung JA, Coakley FV, Vigneron DB,
Swanson MG, Qayyum A, Weinberg V,
Jones KD, Carroll PR, Kurhanewicz J.
Prostate depiction at endorectal MR
spectroscopic imaging: investigation of
a standardized evaluation system.
Radiology 2004;233(3):701-708.
15 Futterer JJ, Scheenen TW, Heijmink SW,
Huisman HJ, Hulsbergen-Van de Kaa CA,
Witjes JA, Heerschap A, Barentsz JO.
Standardized threshold approach using
three-dimensional proton magnetic
resonance spectroscopic imaging in
prostate cancer localization of the entire
prostate. Investigative radiology
2007;42(2):116-122.
16 Kobus T, Hambrock T, Hulsbergen-van de
Kaa CA, Wright AJ, Barentsz JO,
Heerschap A, Scheenen TW. In vivo
assessment of prostate cancer
aggressiveness using magnetic
resonance spectroscopic imaging at 3 T
with an endorectal coil. European
urology;60(5):1074-1080.
17 Scheenen TWJ, Fütterer J, Weiland E and
others. Discriminating cancer from
noncancer tissue in the prostate by
3-dimensional proton magnetic
resonance spectroscopic imaging: A
prospective multicenter validation study.
Invest Radiol 2011;46(1):25-33.
18 Scheenen TW, Heijmink SW, Roell SA,
Hulsbergen-Van de Kaa CA, Knipscheer
BC, Witjes JA, Barentsz JO, Heerschap A.
Three-dimensional proton MR
spectroscopy of human prostate at 3 T
without endorectal coil: feasibility.
Radiology 2007;245(2):507-516.
19 Kobus T, Wright AJ, Scheenen TW,
Heerschap A. Mapping of prostate
cancer by 1H MRSI. NMR Biomed. 2013
Jun 13. doi: 10.1002/nbm.2973. [Epub
ahead of print] PMID:23761200.
Alan Wright
Thiele Kobus
İletişim
Tom Scheenen, Ph.D.
Radboud Üniversitesi Nijmegen
Tıp Merkezi
Radyoloji Bölümü
P.O. Box 9102
6500 HC Nijmegen
Hollanda
[email protected]
100 İnovasyon | Nisan 2014 | www.siemens.com.tr/inovasyon
Arend Heerschap
Tom Scheenen