curriculum vitae - Sabancı University myWeb Service

curriculum vitae - Sabancı University myWeb Service

CURRICULUM VITAE
Name
: Devrim GOZUACIK, MD PhD
Address
: Sabanci University, Faculty of Engineering and Natural Sciences, Biological Sciences and
Bioengineering Program, Orhanli-Tuzla 34956, Istanbul, TURKEY.
Phone/Fax
: +90-216-483 9617 or 90-216-483 9500 / +90-216-483 9550
E-mail
: [email protected]
Web
: http://myweb.sabanciuniv.edu/dgozuacik
EMPLOYMENT,
2011-today, Associate Professor, Biological Sciences and Bioengineering Program, Sabanci University.
Sept. 2006-2011, Assistant Professor, Biological Sciences and Bioengineering Program, Sabanci University.
2001-2006, Postdoctoral fellow, Weizmann Institute of Science (Adi Kimchi Lab).
EDUCATION,
2001, Ph.D. of Molecular Cell Biology, Pasteur Institute, Necker Children’s Hospital-IRNEM, (Christian
Brechot Lab) and Paris-Sud University.
1997, M.Sc. (French D.E.A. degree) of Biochemistry, Ecole Polytechnique (Andrea Parmeggiani Lab) and ParisSud University.
1995, Medical doctor (MD) degree, Hacettepe University, Faculty of Medicine (in English).
1994, Research fellow, Dept. of Tumor Biology, Rotterdam Erasmus Medical Center (Anne Hagemeijer Lab).
1989-1995, Student researcher, Hacettepe Children’s Hospital and Oncology Institute.
AWARDS,
2008: Turkish Academy of Sciences Outstanding Young Scientist Award (TUBA-GEBIP Award).
2006: European Molecular Biology Organization, EMBO, Strategical Development and Installation Award
(EMBO-SDIG Award).
2006: Selected by Roche Pharmaceuticals among the “Leading Bioscientists of the Next Decade”
(Roche Symposium, Basel).
2004-2006: European Union "Marie Curie Actions" Postdoctoral Fellowship.
2002-2004: Weizmann Institute Feinberg Graduate School Postdoctoral Fellowship.
2001-2002: French Organisation For Medical Research (FRM) Postdoctoral Fellowship.
1999-2001: French Cancer Research Association (ARC) PhD Scholarship.
1996-1999: TUBITAK / NATO A1 PhD Full Scholarship.
INCLUSION IN CATALOGUES,
Autophagy Researchers: Devrim Gozuacik. Autophagy 2012, 8 (12) 1709-1709.
Gozuacik D. European Molecular Biology Organization Young Investigator Catalogues 2006 to 2013.
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PROFESSIONAL SERVICES,
A) International professional services,
2010-today: Board of Directors Member, International Cell Death Society (ICDS) (Based in New York).
2010-today: Editorial Board Member, Autophagy journal (Top level journal of the cell biology field. Rank: 12/184.
Impact factor: 12).
2007-2013: Ad hoc referee, Cell Death and Differentiation (Top journal of the cell death field. Impact Factor: 8.4),
Oncogene (Top journal of the cancer field. Impact Factor: 7.4), Human Molecular Genetics (Impact Factor: 7.7), BMC
Cell Biology (Impact Factor: 2.8), Experimental Biology and Medicine (Impact Factor: 2.8), Biotechniques journal
(Impact factor: 2.4), Journal of Oncology.
2008: Ad hoc referee, Cancer Research, UK (Research funding charity in the United Kingdom).
2007: Ad hoc referee, Wellcome Trust, UK (Research funding agency in the United Kingdom).
B) National professional services,
2012- today: Referee, TUBITAK, National Science and Technology Council of Turkey.
2007-2011: Founding member, Turkish Molecular Biology Society (Moleküler Biyoloji Derneği), Turkish Cell
Death Research Society (Hücre Ölümü Araştırma Derneği), MolBioTurk (MBT) National Research Network.
C) Scientific Meeting Organization,
1) International Cell Death Society (ICDS) Conference on Multidisciplinary Approaches in Cell Death
Research, Kemer, Antalya, Turkey, 28-31 May 2010. Organizers: Gozuacik D, Lockshin R, Ozturk M, Zakeri Z.
2) European Molecular Biology Organization (EMBO) International Forum, Bogazici University, Istanbul,
Turkey, 20-22 February 2008. Organizers: Ozoren N, Gozuacik D, Wallon G.
3) International Cell Death Symposium, Istanbul, Turkey, 9 April 2008. Organizers: Ozturk M, Gozuacik D.
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INVITED TALKS AND ORAL PRESENTATIONS,
x
Corresponding author. * First authors with equal contribution.
a) Invited Talks in International Meetings,
1) Gozuacık Dx. miRNAs, autophagy and cancer. EMBO-Cancer YIP Meeting, Antalya, Turkey, 8-10 September
2013.
2) Gozuacık Dx. Novel regulators of autophagy. European Microscopy Society Conference 2013, Regensburg,
Germany, 25-30 August 2013.
3) Gozuacık Dx. miRNA networks regulating autophagy. International Cell Death Society (ICDS) Conference
on: “Mechanisms of cell death”, Malaga, Spain, 6-9 June 2013.
4) Gozuacık Dx. Panelist. International Cell Death Society (ICDS) Conference on: ““Mechanisms of cell
death”, Malaga, Spain, 6-9 June 2013.
5) Gozuacık Dx. Success story. EMBO/EMBL INFO DAY, TUBITAK, Ankara, Turkey, 6 January 2013.
6) Gozuacık Dx. microRNAs: Novel Regulators of cellular stress and death responses. First International
Congress of the Molecular Biology Association, Bogazici University, Istanbul, Turkey, 23-24 November 2012.
7) Gozuacık Dx. Discovery of new autophagy regulators. International Cell Death Society (ICDS) Conference
on: “Cell death: Ageing, Metabolism and Ramifications for Therapeutics and Drug Development”, Singapore,
29 June-1 July 2012.
8) Gozuacık Dx. Session Chair and Panelist. International Cell Death Society (ICDS) Conference on: “Cell
death: Ageing, Metabolism and Ramifications for Therapeutics and Drug Development”, Singapore, 29 June-1
July 2012.
9) Gozuacık Dx. Novel autophagy regulators. EMBO-Cancer YIP Meeting, EMBL, Germany, 2-4 December 2012.
10) Gozuacık Dx. Novel regulators of autophagy. EMBO Forum 2012. Yeditepe University, Istanbul, Turkey, 2012.
11) Gozuacık Dx. Autophagy and cancer. EMBO-Cancer YIP Meeting, King’s College, London, UK, 11-13 July
2011.
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12) Gozuacık Dx. Autophagy, cell death and disease. 4th International Congress of Molecular Medicine, Istanbul,
Turkey, 27-30 June 2011.
13) Gozuacık Dx. New regulators of mammalian autophagy: Implications for cell survival and death. International
Cell Death Society (ICDS) Conference on: “Multidisciplinary Approaches in Cell Death Research” , Kemer,
Antalya, Turkey, 28-31 May 2010.
14) Gozuacık Dx. Session Chair and Panelist. International Cell Death Society (ICDS) Conference on:
“Multidisciplinary Approaches in Cell Death Research”, Kemer, Antalya, Turkey, 28-31 May 2010.
15) Gozuacık Dx. New regulators of autophagy: Implications for Neurological Disorders. Ideas and Initiatives
Genetics of Neurological Disorders Workshop, Bosphorus University, Istanbul, Turkey 15-17 October 2010.
16) Gozuacık Dx. Discovery of interaction partners and regulators of the autophagy and apoptosis protein Atg.
EMBO Conference on "Autophagy: Cell Biology, Physiology and Pathology", Monte Verita, Ascona,
Switzerland, 18-21 October 2009.
17) Gozuacık Dx. Death-associated protein kinase family as an integrator of apoptosis and autophagy. International
Cell Death Society Conference on “Cell Death in Infectious Diseases and Cancer”, Johannesburg, South Africa, 59 June 2009.
18) Gozuacık Dx. Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A. DAPkinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. European
Workshop on Cell Death (EWCD), Hauenstein, Germany, 1-6 June 2008.
19) Gozuacık Dx. Autophagy in Health and Disease. European Molecular Biology Organization (EMBO)
International Forum, Bogazici University, Istanbul, Turkey, 20-22 February 2008.
20) Gozuacık Dx. Autophagic Cell Death. International Cell Death Symposium, Istanbul, Turkey, 9 April 2008.
21) Gozuacık D, Raveh T, Shohat G, Mizushima N, Yoshimori T, Kimchi A. The DAP-Kinase Family of Proteins:
Analysis of their Structure and Function at the Apoptosis/Autophagic Cell Death Junction. Keystone Conference:
Metabolomics: From Bioenergetics to Apoptosis (G5), Snowbird, Utah, USA, 2-7 April 2006.
22) Gozuacık D, Raveh T, Shohat G, Mizushima N, Yoshimori T, Kimchi A. Death-associated protein kinase
(DAPk) is an integrator of apoptosis and autophagic cell death. Roche Symposium for "For leading scientists of the
next decade”, Basel, Switzerland, 29-31 March 2006.
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23) Gozuacık D, Inbal B, Raveh T, Kimchi A. Role of DAP kinase family of proteins in autophagic cell death.
Gordon Research Conference (GRC) on "Autophagy in Stress, Development and Disease", Waterville, Maine,
USA, 22-27 June 2003.
b) Invited Talks in Local Meetings (in Turkish),
1) Gozuacık Dx. Otofaji'yi Düzenleyen Yeni Yolaklar. First Cell Death Research Congress, İzmir, Turkey, 30
October-3 November 2013 (scheduled).
2) Gozuacık Dx. Hücre ölümü ve kanser. Basic Oncology Course during the 20th National Cancer Congress,
Antalya, Turkey, 19-23 April 2013.
3) Gozuacık Dx. Otofaji ve sinyal yolakları. 2nd Theoretical Course on Cell Death Research Techniques,
Eskisehir, Turkey, 01-02 November 2012.
4) Gozuacık Dx. Otofaji analiz yöntemleri ve uygulama aşamaları. 2nd Theoretical Course on Cell Death
Research Techniques, Eskisehir, Turkey, 01-02 November 2012.
5) Gozuacık Dx. Session Chair. 2nd Theoretical Course on Cell Death Research Techniques, Eskisehir, Turkey,
01-02 November 2012.
6) Gozuacık Dx. Otofaji ve hücre ölümü. Programmed Cell Death: Current Approaches Symposium, Acıbadem
University Medical Faculty, Istanbul Turkey, 28 December 2011.
7) Gozuacık Dx. “Otofaji ve sinyal yolakları”. 1st Theoretical Course on Cell Death Research Techniques, Izmir,
Turkey, 24-25 November 2011.
8) Gozuacık Dx. “Otofaji analiz yöntemleri ve uygulama aşamaları”. 1st Theoretical Course on Cell Death
Research Techniques, Izmir, Turkey, 24-25 November 2011.
9) Gozuacık Dx. Hücresel Stres, Otofaji ve Kanser Bağlantısı. 3rd DETEA Conference, Istanbul, Turkey, 17-18
November 2011.
10) Gozuacık Dx. Floresan yöntemlerin hücresel stres ve ölüm araştırmalarında kullanımı. Acıbadem University
Mini Symposium: Fluorescence Techniques, Applications in Biology and Medicine, Istanbul, Turkey, 5 November
2010.
11) Gozuacık Dx. Otofaji ve kanser. 3rd Multidisciplinary Cancer Research Symposium, 14-17 March 2010.
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12) Gozuacık Dx. Tümör baskılayıcı bir mekanizma: Otofaji. 20th National Immunology Congress, Girne, Cyprus,
19-22 November 2009.
13) Gozuacık Dx. Hastalıkta ve sağlıkta hücresel stres yanıtı olarak otofaji. 19th National Electron Microscopy
Congress, Trabzon, Turkey, 22-25 June 2009
14) Gozuacık Dx. Otofajik Hücre Ölümü”. 25th Turkish National Gastroenterology Week, Adana, Turkey, 12-16
November 2008.
15) Gozuacık Dx. Ölümlerden Ölüm Beğen: Otofajik Hücre Ölümü mü Apoptoz mu?” . 10th Turkish National
Medical Biology and Genetics Congress, Belek, Antalya, Turkey, 6-9 September 2007.
c) Oral Presentations (Presenter’s name is in italics),
1) Oz Arslan D, Oral O, Itah Z, Gözüaçık Dx. Otofaji Ve Apoptoz Arasında Yeni Bir Bağlantı: Atg3’ün Kaspaz-8
Tarafından Kesimi. 25th National Biophysics Congress, Trabzon, Turkey, 24-27 September 2013.
2) Koc Bx , Kucukgul C, Ozler B, Karakas HE, Gozuacik Dx. 3D hybrid bioprinting of macrovascular structures. IIE
Annual Conference & Expo 2013. San Juan, Puerto Rico, 18-20 May 2013.
3) Gozuacik Dx, Irmak S, Karakas HE, Koc Bx. Optimized 3D Design and Bioprinting of Cells Based on Autophagy
Analyses. FEBS SPECIAL MEETING/Protein Quality Control in Health and Disease. Kusadasi (Aydin), Turkey,
14-16 November 2012.
4) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacık Dx. Regulation of starvation and rapamycin induced
autophagy by microRNA-376b targeting ATG4C and BECLIN1. FEBS SPECIAL MEETING/Protein Quality
Control in Health and Disease. Kusadasi (Aydin), Turkey, 14-16 November 2012.
5) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. MicroRNA control of autophagy. Keystone
Symposium: Cell Death Pathways: Beyond Apoptosis. Banff, Alberta, Canada, 19-24 March 2012.
6) Oral O*, Oz-Arslan D*, Itah Z, Gozuacık Dx. A novel link between autophagy and apoptosis through caspasemediated cleavage of an Atg protein. International Cell Death Society, Multidisciplinary Approaches in Cell
Death Research From Yeast to Man”, Antalya, Turkey, 28-31 May 2010.
7) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A. Deathassociated protein kinase (DAPk) is an integrator of ER stress-induced apoptosis and autophagic cell death. Ideas and
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Initiatives Genetics of Neurological Disorders Workshop, Bosphorus University, Istanbul, Turkey 15-17 October
2010.
8) Oral O*, Oz-Arslan D*, Itah Z, Gozuacık Dx. Caspase cleaves Atg protein to regulate autophagy. Ideas and
Initiatives Genetics of Neurological Disorders Workshop, Bosphorus University, Istanbul, Turkey 15-17 October
2010.
9) Gozuacik D Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C,
Paterlini-Brechot P. Gene trap in hepatocellular carcinoma by hepatitis B virus DNA insertional mutagenesis
analysis.International Conference on the Molecular Biology of Hepatitis B Virus, Pasteur Institute, Paris, France,
17-21 September 2000.
10) Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C,
Paterlini-Brechot P. Analyse des integrations genomiques du virus de l’hepatite B dans les carcinomes
hepatocellulaires. (Presentation in French). 47th Conference of French Association of Liver Research (AFEF),
Paris, France, 27-29 September 2000.
PATENTS,
Gozuacik D and Korkmaz G (PhD Student). Use of miRNAs for the diagnosis, propylaxis, treatment and follow-up of
diseases involving macroautophagy abnormalities. World Intellectual Property Organization (WIPO)-Patent
Cooperation Treaty (PCT). Patent Number: PCT/TR2010/000192. Month; Year, April 05, 2012. Status: Pending
(Country application phase).
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PUBLICATION LIST,
>1500 total citations in the Science Citation Index, h-Index (SCI): 13.
x
Corresponding author. * First authors with equal contribution.
Original Research and Review Articles,
1) Erbil S*, Oral O*, Mitou G*, Gokce G, Gulacti F, Gozuacik Dx. A scaffold protein is a novel ATG-interactor and
a master autophagy regulator. Submitted.
2) Mitou G*, Erbil S, Gozuacik Dx. A possible link between glycolysis and autophagy. Submitted.
3) Korkmaz G*, Tekirdag AK*, Ozturk DG, Kosar A, Sezerman OU, Gozuacik Dx. miR MIRA is a Regulator of
Starvation-induced Autophagy. Plos One, 2013. Submitted. (Citation Index-SCI, IF: 4.1)
4) Cıkım T, Gozuacik D, Ali Kosar A. Power Reclamation Efficiency of a Miniature Energy Harvesting Device
Using External Fluid Flows (Bio-inspired device). International Journal of Energy Research, 2013. in press.
(Citation Index-SCI, IF: 2.1)
5) Kurtoglu M, Kaya A, Gozuacik D, Yagci Acar HF, and Kosar Ax, " Experimental Study on Heat Transfer
Performance of Iron oxide Based Ferrofluids to be Used as New Generation Coolants and Drug Delivery Agents,"
ASME Journal of Thermal Science and Engineering Applications, 2013. in press.
6) Tekirdag AK, Ozturk DG and Gozuacik Dx. Alteration in autophagic-lysosomal potential during ageing and
neurological diseases: The microRNA perspective. Current Pathobiology Reports, 2013. October; 1(4):1-36.
7) Itah Z, Oral O, Perk OY, Sesen M, Demir E, Erbil S, Dogan-Ekici AI, Ekici S, Kosar A, Gozuacik Dx.
Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue. Experimental Biology
and Medicine, 2013, Nov; 238(11):1-9. (Citation Index-SCI, IF: 2.8)
8) Erzurumlu Y, Kose FA, Gozen O, Gozuacik D, Eric A. Toth EA, Ballar P x. A unique IBMPFD-related p97/VCP
mutation with differential binding pattern and subcellular localization. The International Journal of Biochemistry &
Cell Biology 2013, Apr;45(4):773-82. (Citation Index-SCI, IF: 4.6)
9) Tekirdag KA, Korkmaz G, Ozturk DG, Agami R, Gozuacik Dx. MIR181A regulates starvation- and rapamycininduced autophagy through targeting of ATG5. Autophagy, 2013, Mar 1;9(3):374-85. (Citation Index-SCI, IF: 12)
(Cited 3 times).
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10) Oral O*, Oz-Arslan D*, Zeynep Itah, Naghavi A, Deveci R, Karacali S, Gozuacik Dx. Cleavage of Atg3 protein
by caspase-8 regulates autophagy during receptor-activated cell death. Apoptosis, 2012, Aug;17(8):810-20. (Citation
Index-SCI , IF: 4.8) (Cited 6 times).
11) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. miR-376b controls starvation and mTOR
inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy, 2012 February; 8 (2): 1-12. (Citation
Index-SCI, IF: 12) (Cited 16 times).
12) Klionsky DJ et al. (“International Autophagy Consortium” including Gozuacik D). Guidelines for the use and
interpretation of assays for monitoring autophagy. Autophagy, 2012 April; 8 (4): 1-100. (Citation Index-SCI, IF: 12)
(Cited 113 times).
13) Kuzuoglu D, Cebeci-Yalcınkaya O, Akpinar BA, Mitou G, Korkmaz G, Gozuacık D, Budak Hx. Autophagyrelated gene, TdAtg8, in wild emmer wheat plays a role in drought and osmotic stress response. Planta 2012, DOI:
10.1007/s00425-012-1657-3. (Citation Index-SCI, IF: 3) (Cited 1 times).
14) Perk OY, Sesen M, Gozuacik D, Kosar Ax. Kidney stone erosion by hydrodynamic cavitation and consequent
kidney stone treatment. Annals of Biomedical Engineering, 2012, 2012, Sep; 40(9): 1895-902. (Citation Index-SCI,
IF: 2.4)
15) Kosar Ax, Sesen M, Oral O, Itah Z and Gozuacik Dx. Bubbly cavitating flow generation and investigation of its
erosional nature for biomedical applications. IEEE Transactions on Biomedical Engineering, 2011 May;58(5):
1337-46. (Citation Index-SCI, IF: 2.3) (Cited 2 times).
16) Öz-Arslan D, Korkmaz G, Gözüaçık Dx. Otofaji: Bir hücresel stres yanıtı ve ölüm mekanizması (in Turkish).
Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 2011 October 2(4), pages 184-94. Review (Turkish Citation Index,
Türk Atıf İndeksi).
17) Mitou G, Budak H, and Gozuacik Dx. Techniques to Study Autophagy in Plants. International Journal of Plant
Genomics, 2009, Article ID 451357, 14 pages, 2009. doi:10.1155/2009/451357. Review (Scopus, Chemical Abstracts,
PubMed, Google Scholar) (Cited 15 times).
18) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A x. DAPkinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death
and Differentiation, 2008 15(12): 1875-86. (Citation Index-SCI, IF: 9) (Cited 72 times).
19) Gozuacik D and Kimchi Ax. Autophagy and cell death. Current Topics in Developmental Biology, 2007 78:
217-45. Review. (IF: 6) (Cited 175 times).
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20) Gozuacik D and Kimchi Ax. DAPk protein family and cancer. Autophagy, 2006 2(2): 74-79. Review. (IF: 7.5)
(Cited 67 times)
21) Llambi F, Calheiros F, Gozuacik D, Pays L, Del Rio G, Kimchi A, Mehlen P x. The dependence receptor
UNC5H2 mediates apoptosis through DAP kinase. EMBO Journal, 2005 Mar 23;24(6):1192-201. (IF: 9) (Cited 74
times)
22) Shani G, Marash L, Gozuacik, D, Bialik S, Teitelbaum L, Shohat G and Kimchi A x. Death-associated protein
kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions (Autophagic
cell death induction by ZIP kinase). Molecular and Cellular Biology, 2004 24(19):8611-26. (IF: 6) (Cited 47 times)
23) Gozuacik D and Kimchi Ax. Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 2004
23(16):2891-906. Review. (Selected by Thomson Reuters as one of the 48 core papers on autophagy.). (IF: 7)
(Cited 588 times)
24) Gozuacik D, Chami M, Murakami Y, Faivre J, Lagorce D, Poch O, Biermann O, Knippers R, Bréchot C,
Paterlini-Bréchot Px. Identification and functional characterization of a new member of the human Mcm protein
family: hMcm8. Nucleic Acids Research, 2003 Jan 15;31(2):570-9. (IF: 7.4) (Cited 48 times).
25) Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Brechot C x. Hepatitis
B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human
telomerase gene. Oncogene, 2003 Jun 19;22(25):3911-6. (IF: 7) (Cited 3 times).
26) Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Brechot C,
Paterlini-Brechot Px. Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA
tagging. Oncogene, 2001 Sep 27;20(43):6233-40. (IF: 7) (Cited 55 times).
27) Chami M*, Gozuacik D*, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le
Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P x. SERCA1 truncated proteins unable to pump calcium reduce the
endoplasmic reticulum calcium concentration and induce apoptosis. Journal of Cell Biology, 2001 Jun 11;153(6):
1301-14. (IF: 10) (Cited 34 times).
28) Brechot C x, Gozuacik D, Murakami Y, Paterlini-Brechot P. Molecular bases for the development of hepatitis B
virus (HBV)-related hepatocellular carcinoma (HCC). Seminars in Cancer Biology, 2000 Jun;10(3):211-31. Review.
(IF: 7.6) (Cited 139 times).
29) Chami M*, Gozuacik D*, Saigo K*, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML,
Claret M, le Maire M, Brechot C, Paterlini-Brechot P x. Hepatitis B virus-related insertional mutagenesis implicates
SERCA1 gene in the control of apoptosis. Oncogene, 2000 Jun 8;19(25): 2877-86. (IF: 7) (Cited 33 times).
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Book Chapters,
1) Tekirdag AK, Ozturk DG, Gozuacık Dx. Regulation of autophagy by miRNAs. Pages:. In the book:
AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Hayat MA, (Ed). Elsevier
Academic Press, in preparation.
2) Eberhart K, Oral O, Gozuacık Dx. Induction of autophagic cell death by anticancer agents. Pages: 179-202. In the
book: AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Hayat MA, (Ed).
Elsevier Academic Press 2013, ISBN: 978-012-405530-8
3) Oral O, Irmak S, Ekici S, Gözüaçık Dx. Ürolojide otofaji (Autophagy in Urology). Pages: 271-283. In the book:
Moleküler Üroloji (in Turkish). Türkeri L, Ozer A, Narter F, (Eds). Üroonkoloji Derneği Publishing. 2012.
ISBN:978-975-01697-2-4.
4) Gozuacık Dx. “Otofaji ve sinyal yolakları” ve (Autophagy and signal pathways). Pages 49-60. In the book: IInd
Theoretical Course on Cell Death Research Techniques (in Turkish). Eskisehir Osmangazi University Press. 2012.
ISBN No: 978-975-7936-95-4.
5) Gozuacık Dx. “Otofaji analiz yöntemleri ve uygulama aşamaları” (Autophagy analysis techniques and application
steps). Pages 133-146. In the book: IInd Theoretical Course on Cell Death Research Techniques (in Turkish).
Eskisehir Osmangazi University Press. 2012. ISBN No: 978-975-7936-95-4.
6) Gozuacık Dx. “Otofaji ve sinyal yolakları” ve (Autophagy and signal pathways). Pages 53- 61. In the book: Ist
Theoretical Course on Cell Death Research Techniques (in Turkish). Dokuz Eylul University Press, 2011. ISBN
No: 978-975-441-349-6.
7) Gozuacık Dx. “Otofaji analiz yöntemleri ve uygulama aşamaları” (Autophagy analysis techniques and application
steps). Pages 129-141. In the book: Ist Theoretical Course on Cell Death Research Techniques (in Turkish).
Dokuz Eylul University Press, 2011. ISBN: 978-975-441-349-6.
8) Paterlini-Brechot P x, Chami M and Gozuacik D. “Calcium ATPase Genes and Cell Transformation”. Pages 505520. In the book: Calcium, The Molecular Basis of Calcium Action in Biology and Medicine. Pochet R, Donato
R, Haiech J, Heizmann CW, Gerk V (Eds.). Springer Publishing, 2001. ISBN: 0-7923-6421-X.
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Engineering Conference Papers,
1) Kucukgul C, Ozler B, Karakas, HE, Gozuacik Dx, Koc Bx. 3D hybrid bioprinting of macrovascular structures.
3rd ECCOMAS Thematic Conference on Tissue Engineering (ICTE), Leiria, PORTUGAL, JUN 06-08, 2013.
Procedia Engineering , 59, Pages: 183-192 DOI: 10.1016/j.proeng.2013.05.109.
2) Kurtoğlu M, Kaya A., Gozuacik D, Yagci Acar, HF, and Koşar Ax. Heat Transfer Enhancement With Iron Oxide
Nanoparticle Based Ferrofluids," Proceedings of the ASME 2013 11th International Conference on Nanochannels,
Microchannels, and Minichannels, ICNMM 11, Sapporo, Japan, June, 2013, ICNMM2013-73146.
3) Cıkım TA, Tatar O, Kaya, A, Gozuacık D and Kosar Ax. Power reclamation of a bio-inspired miniature device
using internal flows. ASME, International Mechanical Engineering Conference Congress and Exhibition,
Houston, Texas, 2012.
4) Cıkım, T., Kaya, A., Gozuacik, D. and Kosar, A., "Power reclamation efficiency of a bio inspired miniature
energy harvesting device using internal fluid flows", Global Conference on Global Warming-2012, Istanbul,
Istanbul Technical University.
5) Kosar Ax, Akbas A, Sahin O, Kubilay A, Oral O, Gozuacik Dx. Bubbly cavitating flow generation and
investigation of its erosional nature for biomedical applications. 2nd Micro and Nano Flows Conference, 2009,
Pages: 1-7. MNF2009. ISSN: 978-1-902316-72-7, ISBN: 978-1-902316-73-4.
6) Bilen H, Hocaoglu MA, Baran EA, Unel Mx, Gozuacik D. Novel Parameter Estimation Schemes in
Microsystems. IEEE International Conference on Robotics and Automation, 2009, Pages: 2394-2399. ISSN:
1050-4729, ISBN: 978-1-4244-2788-8.
Published Abstracts,
1) Gozuacik Dx, Irmak S, Karakas HE, Koc Bx. Optimized 3D design and bioprinting of a blood vessel based on
autophagy analyses. Journal of Tissue Engineering and Regenerative Medicine, 2012 Sept.; 6 (Supplement: 1):
377-377
2) Gozuacık Dx. Autophagy, cell death and disease. In vivo, 2011 May-June; 25 (3): 484-484.
3) Reef S, Gozuacik D, Zalckvar E, Bialik S, Shoval Y, Kimchi A x. The road map to programmed cell death:
Switching between apoptosis and autophagic cell death. Autophagy, 2006 Oct; 2 (4): 343-343.
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4) Gozuacik D, Murakami Y, Saigo K, Chami M, Okanoue T, Urashima T, Kenmochi T, Ochiai T, Brechot C,
Paterlini-Brechot P x. Gene trap in hepatocellular carcinoma (HCC) by hepatitis B virus (HBV) DNA insertional
mutagenesis analysis. Journal of Hepatology, 2001 Apr; 34: 100-100 Supp.1.
5) Chami M*, Gozuacik D* , Saigo K*, Capiod T, Falson P, Torchard D, Caudron B, Urashima T, Isono K,
LeMaire M, Beckman J, Claret M, Brechot C, Brechot P x. In vivo targeting of SERCA1 gene by hepatitis B virus
(HBV) DNA integration in a human hepatocellular carcinoma. Biophysical Journal, 1999 Jan; 76 (1): A381-A381
Part 2.
6) Chami M*, Saigo K*, Gozuacik D * , Poussin K, Falson P, Torchard D, Clepet C, Gyapay G, Caudron B,
Urashima T, Kew M, Isono K, Le Marie M, Beckman J, Weissenbach J, Brechot C, Paterlini P x. HBV related
insertional mutagenesis leads to hyperexpression of a HBV X SERCA 1 hybrid protein in a human hepatocellular
carcinoma. Hepatology, 1998 Oct; 28 (4): 1278 Part 2 Suppl. S.
Poster Presentations (Presenter’s name is in italics),
1) Tekirdag KA*, Korkmaz G*,Ozturk DG, Agami R, Gozuacik Dx. MIR181A regulation of autophagy by targeting
ATG5. ICDS meeting. Malaga, Spain. 6 June.-9 June.2013.
2) Karakas HE, Koc B, Gozuacik Dx. Analysis of the role of autophagy in tissue engineering studies. 2013
TERMIS-EU Conference. Istanbul, Turkey, 17- 20 June. 2013.
3) Korkmaz G, Tekirdag KA, Gozuacik Dx. Investigation of the effect of miR-376b on target protein levels by SDSPAGE and Western Blotting.EMBO YIP PhD. Course. Heidelberg,Germany. 9-15 Sept. 2012.
4) Gozuacik Dx, Karakas HE, Oral O, Irmak S, Koc Bx. Optimized 3D Design and Bioprinting of a Blood Vessel
based on Autophagy, 3rd Stem Cell Symposium, Istanbul, Turkey, 30 Nov.- 1 Dec. 2012.
5) Gozuacik Dx, Karakas HE, Oral O, Irmak S, Koc Bx. Optimized 3D Design and Bioprinting of a Blood Vessel
based on Autophagy, 1st International Congress of the Molecular Biology Association of Turkey, Istanbul,
Turkey, 23- 24 Nov.2012.
6) Mitou G, Oral O, Bayraktar O, Gozuacik Dx. A novel link between glycolysis and autophagy. FEBS SPECIAL
MEETING/Protein Quality Control in Health and Disease. Kusadasi (Aydin), Turkey, 14-16 November 2012.
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7) Oz-Arslan D, Oral O, Itah Z, Gozuacik Dx. A novel link between autophagy and apoptosis: Cleavage of Atg3
protein by caspase-8. FEBS SPECIAL MEETING/Protein Quality Control in Health and Disease. Kusadasi
(Aydin), Turkey, 14-16 November 2012.
8) Gozuacik Dx, Irmak S, Karakas HE, Koc Bx. Optimized 3D Design and Bioprinting of Cells Based on Autophagy
Analyses. FEBS SPECIAL MEETING/Protein Quality Control in Health and Disease. Kusadasi (Aydin), Turkey,
14-16 November 2012.
9) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacık Dx. Regulation of starvation and rapamycin induced
autophagy by microRNA-376b targeting ATG4C and BECLIN1. FEBS SPECIAL MEETING/Protein Quality
Control in Health and Disease. Kusadasi (Aydin), Turkey, 14-16 November 2012.
10) Oral O, Oz-Arslan D, Itah Z, Kosar A, Ekici S, Dogan-Ekici AI, Naghavi A, Deveci R, Karacali S, Gozuacik Dx.
Cleavage of Atg3 protein by caspase-8 regulates autophagy. 6th International Symposium on Autophagy. Okinawa,
Japan, 28 Oct.- 1 Nov. 2012.
11) Gozuacik Dx, Karakas HE, Oral O, Irmak S, Koc B x. Optimized 3D Design and Bioprinting of Cells Based on
Autophagy Analyses. 3rd TERMIS World Congress 2012: “Tissue Engineering and Regenerative Medicine”.
Vienna, Austria, 5-8 Sept. 2012.
12) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. MicroRNA Control of Autophagy. Gordon
Research Conference (GRC) on Autophagy in Stress, Development and Disease, Autophagy - A Biomedical
Paradigm. Ventura, CA, USA, 11-16 March 2012.
13) Korkmaz G, le Sage C, Tekirdag AK, Agami R, Gozuacik Dx. miR-376b controls starvation and mTOR
inhibition-related autophagy by targeting ATG4C and BECN1. EACR Conference on Cell Death in Cancer.
Amsterdam, The Netherlands, 26-28 January 2012.
14) Mitou G, Gulacti F, Gozuacık Dx. A glycolysis enzyme is a new autophagy protein. 2nd EMBO Conference on
Autophagy in health and disease. Ma'ale Hachamisha, Israel, 30 October - 4 November, 2011.
15) Korkmaz G, Sage C, Agami R, Gozuacık Dx. Autophagy-regulating miR-376b as a novel nanoparticle deliverable
drug. 7th Nanoscience and Nanotechnology Conference, Sabanci University, Istanbul, Turkey, 27 June-01 July
2011.
16) Korkmaz G, Tekirdag AK, le Sage C, Agami R, Gozuacik Dx. Potential of nanoparticle delivery of new
microRNA-based drugs.7th Nanoscience and Nanotechnology Conference, Sabanci University, Istanbul, Turkey,
June 27- July 01, 2011.
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17) Itah Z, Şeşen M , Oral O , Koşar A and Gozuacik Dx. Biomedical use of nano-micro bubbles produced by
hydrodynamic cavitation. 7th Nanoscience and Nanotechnology Conference, Sabanci University, Istanbul, Turkey,
27 June-01 July 2011.
18) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T and Kimchi A.
Death-associated protein kinase (DAPk) is an integrator of ER stress-induced apoptosis and autophagic cell death.
Ideas and Initiatives Genetics of Neurological Disorders Workshop, Bosphorus University, Istanbul, Turkey 15-17
October 2010.
19) Kuzuoglu D, Yalcinkaya OC, Korkmaz G, Gozuacik D, Budak H. “Cloning and functional analysis of Autophagy
related gene, Atg, from Brachypodium and wild emmer wheat under abiotic stress”. PAG-XVIII, Plant and Animal
Genome XVIII Conference, Town & Country Convention Center, San Diego, California, USA, January 9-13, 2010.
20) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T and Kimchi A.
Death-associated protein kinase (DAPk) is an integrator of ER stress-induced apoptosis and autophagic cell death.
International Cell Death Society, Multidisciplinary Approaches in Cell Death Research From Yeast to Man”,
Antalya, Turkey, 28-31 May 2010.
21) Itah Z, Oral O , Şeşen M, Koşar A and Gozuacik Dx. Exploration of the cell killing effects of hydrodynamic
cavitation”. International Cell Death Society, Multidisciplinary Approaches in Cell Death Research From Yeast
to Man”, Antalya, Turkey, 28-31 May 2010.
22) Korkmaz G, Sage C, Agami R, Gozuacık Dx. miRNA regulation of autophagy”. International Cell Death
Society, Multidisciplinary Approaches in Cell Death Research From Yeast to Man”, Antalya, Turkey, 28-31 May
2010.
23) Korkmaz G, Agami R and Gozuacik Dx. miRNA regulation of autophagy.”. The 17th Euroconference on
Apoptosis: Destruction, Degradation and Death, Institut Pasteur, Paris, France, 23-26 September 2009.
24) Gozuacik D, Bialik S, Raveh T, Mitou G, Shohat G, Sabanay H, Mizushima N, Yoshimori T, Kimchi A. Death
Associated Protein Kinase is an integrator of autophagy and apoptosis. The 17th Euroconference on Apoptosis:
Destruction, Degradation and Death, Institut Pasteur, Paris, France, 23-26 September 2009.
25) Gulacti F*, Mitou M*, Gozuacik Dx. Discovery of interaction partners and regulators of the autophagy and
apoptosis protein Atg. European Workshop on Cell Death (EWCD), Hauenstein, Germany, 1-6 June 2008.
26) Gulacti F*, Mitou M*, Nalbant SI, Akcaylar HI, Erman B, Gozuacik Dx. Atg is a key regulatory molecule in
autophagy pathways. European Molecular Biology Organization (EMBO) International Forum, Bogazici
University, Istanbul, Turkey, 20-22 February 2008.
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27) Bilen H, Hocaoglu MA, Korkmaz G, Unel M, Gozuacik D. Robotic manipulation of cells: An integrated visual
survoing and force approach. European Molecular Biology Organization (EMBO) International Forum, Bogazici
University, Istanbul, Turkey, 20-22 February 2008.
28) Gozuacik D, Raveh T, Shohat G, Mizushima N, Yoshimori T and Kimchi A. Death-associated protein kinase
(DAPk) is an integrator of apoptosis and autophagic cell death. Gordon Research Conference (GRC) on Autophagy
in Stress, Development and Disease, Ventura, CA, USA, 6-11 January 2008.
29) Gozuacik D, Raveh T, Shohat G, Mizushima N, Yoshimori T and Kimchi A. Death-associated protein kinase
(DAPk) is an integrator of apoptosis and autophagic cell death. Keystone Symposium: Autophagy in Health and
Disease, Monterey, CA, USA, 15-20 April 2007.
30) Gozuacik D, Raveh T, Shohat G, Mizushima N, Yoshimori T, Kimchi A. DAP kinase is a key mediator of stressinduced cell death. Federation of Israeli Societies on Experimental Biology (FISEB) Conference, Eilat, Israel. 7-10
February 2000.
31) Chami M*, Gozuacik D*, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le
Maire M, Rizzuto R, Brechot C, Paterlini-Brechot P. SERCA1-T a new SERCA1 truncated protein involved in cell
proliferation and apoptosis. 4th European Calcium Society (ECS) Meeting on Calcium Binding Proteins, Brussels,
Belgium, 11-14 April 2000.
32) Chami M*, Gozuacik D*, Saigo K*, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML,
Claret M, le Maire M, Brechot C, Paterlini-Brechot P. In vivo targeting of SERCA1 gene by hepatitis B virus DNA
integration in a human hepatocellular carcinoma. 43rd Annual Meeting of the Biophysical Society, Baltimore,
Maryland, USA, 13-17 February 1999.
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