ÖZGEÇMİŞ Duzkale, Hatice - Tıp Fakültesi

ÖZGEÇMİŞ Duzkale, Hatice - Tıp Fakültesi

ÖZGEÇMİŞ
1. Adı Soyadı
İletişim Bilgileri
Adres
Telefon
Mail
: Hatice Düzkale
: Genetik Tanı Merkezi İbrahimağa Mah. Köftüncü Sok. İstek Vakfı
No: 57/1 34718 Acıbadem-Kadıköy-İstanbul
: (0531) 761 5669
: [email protected]
2. Doğum Tarihi
:
3. Unvanı
: Doktor [M.D., M.P.H., Ph.D., D.A.B.M.G (Diplomate of the American
Board of Medical Genetics)]
4. Öğrenim Durumu
: Doktora sonrası eğitim tamamlanmıştır.
Derece
Lisans
Yüksek Lisans
Doktora
Alan
Tıp Fakültesi
Üniversite
Ankara Üniversitesi
Teksas Üniversitesi Halk Sağlığı
Halk Sağlığı
Fakültesi, Houston
Teksas Üniversitesi Biyomedikal
Biyomedikal Bilimler
Bilimler Fakültesi ve MD
(Tıbbi Genetik Doktorası
Anderson Kanser Merkezi,
YÖK denkliği; Nisan 2013)
Houston
Yıl
04/1998
08/2003
08/2011
5. Akademik Unvanlar
Araştırma Görevlisi (Teksas Üniversitesi Halk Sağlığı Fakültesi, Houston;
Teksas Üniversitesi Biyomedikal Bilimler Fakültesi ve MD Anderson Kanser Merkezi,
Houston)
Postdoctoral Fellow (Harvard Tıp Fakültesi, Klinik Moleküler Genetik Eğitim Programı)
Yardımcı Doçentlik Tarihi: 01.Mart.2014
6.1. Yüksek Lisans Tezleri
Duzkale, Hatice, “Molecular Haplotypes of the Sulfotransferase 2A1 Gene for Investigating
Genetic Susceptibility for Ischemic Heart Disease” (2003). UT School of Public Health
(MPH Thesis)
6.2. Doktora Tezleri
Duzkale, Hatice, "LDOC1, A NOVEL BIOMARKER OF PROGNOSIS IN CHRONIC
LYMPHOCYTIC LEUKEMIA" (2011). UT GSBS Dissertations and Theses (Open Access).
Paper 161 (Dissertation)
http://digitalcommons.library.tmc.edu/utgsbs_dissertations/161/
7. Yayınlar
7.1. Uluslar arası hakemli dergilerde yayınlanan makaleler
1. Jamuar SS, Duzkale H, Duzkale N, Zhang CS, High FA, Kaban L, Bhattacharya S, Crandall B.,
Kantarcı S, Stoler JM, Lin AE.
Deletion of Chromosome 8q22.1, a Critical Region for Nablus Mask-Like Facial Syndrome: Four
Additional Cases Support a Role of Genetic Modifiers in the Manifestation of the Phenotype. The
American Journal of Human Genetics (baskida)
2. Catherine A. Brownstein, Alan H. Beggs, Nils Homer, Barry Merriman, Timothy W. Yu, Katherine C.
Flannery, Elizabeth T. DeChene, Meghan C. Towne, Sarah K. Savage, Emily N. Price, Ingrid A. Holm,
Lovelace J. Luquette, Elaine Lyon, Joseph Majzoub Peter Neupert, David McCallie Jr, Peter Szolovits,
Huntington F. Willard, Nancy J Mendelsohn, Renee Temme, Richard S. Finkel, Sabrina W. Yum, Livija
Medne, Shamil R. Sunyaev, Ivan Adzhubey, Christopher A. Cassa, Paul I.W. de Bakker, Hatice
Duzkale, Piotr Dworzyński, William Fairbrother, et al.
An international effort towards developing standards for best practices in analysis, interpretation and
reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biology 2014,
15(3):R53
3. H Duzkale, J Shen, H McLaughlin, A Alfares, MA Kelly, TJ Pugh, BH Funke, HL Rehm, MS Lebo.
A systematic approach to assessing the clinical significance of genetic variants. Clin Genet. 2013
Nov;84(5):453-63 (Invited Original Article) PMID: 24033266
4. Duzkale H, Schweighofer CD, Coombes KR, Barron LL, Ferrajoli A, O'Brien S, Wierda WG, Pfeifer
J, Majewski T, Czerniak BA, Jorgensen JL, Medeiros LJ, Freireich EJ, Keating MJ, Abruzzo LV.
LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts
overall survival in untreated patients. Blood. 2011 Apr 14;117(15):4076-84. [Epub 2011 Feb 10]
5. Golemovic M, Quintás-Cardama A, Manshouri T, Orsolic N, Duzkale H, Johansen M, Freireich EJ,
Kantarjian H, Zingaro RA, Verstovsek S.
MER1, a novel organic arsenic derivative, has potent PML-RARalpha- independent cytotoxic activity
against leukemia cells. Invest New Drugs. 2010 Aug;28(4):402-12. [Epub 2009 May 26] PMID:
19468689
6. Sullivan LS, Bowne SJ, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Lewis RA, Garcia CA,
Ruiz RS, Blanton SH, Northrup H, Gire AI, Seaman R, Duzkale H, Spellicy CJ, Zhu J, Shankar SP,
Daiger SP.
Prevalence of disease-causing mutations in families with autosomal dominant retinitis pigmentosa: a
screen of known genes in 200 families. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3052-64. PMID:
19468689
7. Duzkale H, Pagliaro LC, Rosenblum MG, Varan A, Liu B, Reuben J, Wierda WG, Korbling M,
McMannis JD, Glassman AB, Scheinberg DA, Freireich EJ.
Bone marrow purging studies in acute myelogenous leukemia using the recombinant anti-CD33
immunotoxin HuM195/rGel. Biol Blood Marrow Transplant. 2003 Jun;9(6):364-72. PMID: 12813444
8. Duzkale H, Jilani I, Orsolic N, Zingaro RA, Golemovic M, Giles FJ, Kantarjian H, Albitar M,
Freireich EJ, Verstovsek S.
In vitro activity of dimethylarsinic acid against human leukemia and multiple myeloma cell lines. Cancer
Chemother Pharmacol. 2003 May;51(5):427-32. Epub 2003 Mar 26 PMID: 12736761
7.2. Uluslar arası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceeding) basılan bildiriler.
1. H. Duzkale. Call for a Standardized Genetics Clinical Laboratory Specialty Training Across the
Globe: An Initiative for Clinical Molecular Genetics Training in Turkey [Accepted for poster presentation
at ESHG 2014 Annual Meeting; Milan, Italy, May-June 2014]
2. B.H. Funke, M.J. Bowser, S. Gowrisankar, H. Duzkale, S.S. Amr, O. Ceyhan-Birsoy, J. Shen, E.
Hynes, L.M. Mahanta, H.L. Rehm, T.J. Pugh. Enhancing the Clinical Utility of Targeted Next-Generation
Sequencing by Incorporating Systematic High Resolution Copy Number Analysis [AMP 2013 Annual
Meeting; Phoenix, AZ, Nov 2013 2013]
3. H Duzkale, J Shen, H McLaughlin, A Alfares, MA Kelly, TJ Pugh, BH Funke, HL Rehm, MS Lebo.A
systematic approach to assessing the clinical significance of genetic variants. [poster: ASHG 2013
Annual Meeting in Boston, MA, Oct 2013]
4. Jamuar SS, Duzkale H, Duzkale N, Zhang CS, High FA, Kaban L, Bhattacharya S, Stoler JM, Lin AE.
3 additional cases add support that del 8q22.1 is necessary but not sufficient to cause the Nablus masklike facial syndrome phenotype [poster: ASHG 2013 Annual Meeting in Boston, MA, Oct 2013]
5. J. Shen, MS Lebo, S.S. Amr, H. Duzkale, T.J. Pugh, E.D Hynes, B. Harrison, A.L.
Hernandez, K.A. Lafferty, J.B. Moeschler, S. Upton, S. Gowrisankar, D. Mandelker, D.P. Corey, H.L.
Rehm. Integrating Linkage and Copy Number Variation analyses with Genome Sequencing in the clinical
diagnosis of hearing loss. [The 9th Molecular Biology of Hearing and Deafness Conference; Stanford
School of Medicine, June 22-25, 2013; Palo Alto, CA]
6. Droplet Digital PCR (ddPCR) Validated as a Sensitive Test for Measurement of Copy Number
Alterations in Cancer. [Davetli konuşmacı]. Molecular Medicine TRICONFERENCE, Inaugural
Quantitative Real Time PCR Symposium, February 11-15, 2013, San Francisco, CA
7. H. Duzkale, C.D. Schweighofer, K.R. Coombes, L.L. Barron, E. J Freireich, M.J. Keating, L.V.
Abruzzo. LDOC1 mRNA Is Differentially Expressed in Chronic Lymphocytic Leukemia and Predicts
Overall Survival in Untreated Patients. [Keystone Symposium: Changing Landscape of the Cancer
Genome June 20-24, 2011; Boston, MA]
8. H. Duzkale, C.D. Schweighofer, K.R. Coombes, L.L. Barron, E. J Freireich, M.J. Keating, L.V.
Abruzzo. LDOC1 mRNA Is Differentially Expressed in Chronic Lymphocytic Leukemia and Predicts
Overall Survival in Untreated Patients.[ UTMDACC Symposia on Cancer Research 2010: Personalized
Cancer Therapy and Prevention; October 8-9, 2010; Houston, TX]
9. H. Duzkale, C.D. Schweighofer, K.R. Coombes, L.L. Barron, E. J Freireich, M.J. Keating, L.V.
Abruzzo. LDOC1 mRNA Is Differentially Expressed in Chronic Lymphocytic Leukemia and Predicts
Overall Survival in Untreated Patients. [Hematologic Malignancies 2010-Sixth International Conference;
October 13-16, 2010; Houston, TX]
10. M.I. Coolbaugh-Murphy, J. Xu, L.S. Ramagli, H. Duzkale, C. Fogler, M.L. Fraizer, B.W. Brown,
M.J. Siciliano. Microsatellite instability (MSI) increases with the age of normal individuals and supports
the significance of higher MSI levels in constitutive tissues of HNPCC patients. Proceedings of American
Association for Cancer Research 2005, 46: abstract #1315 [AACR 96th Annual Meeting 2005, Anaheim,
CA]
11. M. Golemovic, H. Kantarjian, N. Orsolic, R. Zingaro, M-Z. Gao, X. Cheng, M. Johansen, H.
Duzkale, P. Tinkey, T. Lembo, C. V. Pelt, L.A. Trissel, F. Giles, J. Cortes, E. J Freiereich, S. Verstovsek.
Development of an arsenic derivative as a therapy for leukemia. Blood November 16, 2003, 102(11):
Abstract #4733 [ASH 45th Annual Meeting 2003, San Diego, CA]
12. S. Verstovsek, H. Duzkale, N. Orsolic, R. Zingaro, F. Giles, J. Cortes et al. SDimethylarsinothiosuccinic acid, an organic arsenic derivative, is comparable in in vitro anti-leukemic activity to arsenic
trioxide but possesses significantly less toxicity [abstract]. Blood 100 (2002), p. 271b [ASH 44th Annual
Meeting 2002, Philadelphia, PA]
13. H. Duzkale, L. C. Pagliaro, M. Rosenblum, J. D. McMannis, D. A. Scheinberg, Emil J Freireich.
Purging Studies of Bone Marrow Utilizing anti-CD33 Immunotoxin HuM195/rGel. Proceedings of the
American Association for Cancer Research, March 2002, abstract # 3726 [AACR 93rd Annual Meeting
2002, San Francisco, CA
14. H. Duzkale, I. Jilani, F. Onida, R. Zingaro, B. Liu, H. M. Kantarjian, L. C. Pagliaro, E. J Freireich.
“Dimethylarsinic Acid as an Effective Compound on Hematologic Malignancies In Vitro". Blood,
November 16, 2000, 96(11):115a, abstract #493 [ASH
42nd Annual Meeting 2000, San Francisco, CA]
15. H. Duzkale, B. Liu, L. C. Pagliaro, M. Korbling, M. Rosenblum, A. M. Tsimberidou, H. Kantarjian,
B. S. Andersson, M. Beran, A. Keyhani, E. J Freireich. Human Bone Marrow Purging with Anti-CD33
Immunotoxin. Proceedings of the American Association for Cancer Research, March 2000, 41:287,
abstract #1825 [AACR 91st Annual Meeting 2000, San Francisco, CA]
7.3. Yazılan Uluslar arası kitaplar veya kitaplarda bölümler.
7.4. Ulusal hakemli dergilerde yayınlanan makaleler
7.5. Ulusal bilimsel toplantılarda sunulan bildiri kitabında basılan bildiriler
7.6 Diğer Yayınlar
Duzkale, Hatice, "LDOC1, A NOVEL BIOMARKER OF PROGNOSIS IN CHRONIC
LYMPHOCYTIC LEUKEMIA" (2011). UT GSBS Dissertations and Theses (Open Access). Paper 161
(Dissertation)
http://digitalcommons.library.tmc.edu/utgsbs_dissertations/161/
Nisan 2014 tarihi itibariyle 137 kez indirilmiştir.
8.Bilimsel Kuruluşlara Üyelikleri
American Association for Cancer Research (AACR) 2009Aralık 2013’ten itibaren active member
American Society of Human Genetics (ASHG) 20119.Ödüller
1. Patentler (34 adet A.B.D. ve International Patent) (2003-2011)
S-Dimethylarsino-Thiosuccinic Acid, S-Dimethylarsino-2-Thiobenzoic Acid, S(Dimethylarsino) Glutathione As Treatments for Cancer, Compounds and Methods for the Treatment of
Cancer
Zingaro, Ralph A.; Freireich, Emil J; Duzkale, Hatice; Kantarjian, Hagop; Verstovsek,
Srdan; Sotelo-Lerma, Merida
[S-(Dimethylarsino) Glutathione (ZIO-101 or Darinaparsin/Zinapar) şu anda böbrek kanseri, karaciğer
kanseri, myeloma ve lösemi/lenfoma tedavisi amacıyla Faz II klinik çalışmalarda kullanılmaktadır
(ZioPharm Oncologies).
2. ESHG 2014 Meeting Conference Fellowship
Call for a Standardized Genetics Clinical Laboratory Specialty Training Across the Globe: An Initiative
for Clinical Molecular Genetics Training in Turkey” başlıklı özet için ESHG bilimsel kurulu fellowluk
ödülü uygun görmüştür.
2. Partners in Excellence Ekip Ödülü (12/2013)
Laboratory for Molecular Medicine, Partners HealthCare Center for Personalized Genetic Medicine.
Ekip ödülü: Otogenome Next Gen sekanslama test panelinin 71 sağırlık geni için kullanıma sunumu
3. CLARITY Challenge Ekip Ödülü (Birincilik) (11/2012)
Harvard Medical School & affiliated hospitals team (22 kişi)
20 grubun katıldığı uluslararası bir yarışma. 3 ayrı genetik hastalığı bulunan ailede genetik etyolojinin
whole genome/exome sekanslama ile tespitinde genome analizi, yorumu ve rapor edilmesindeki en iyi
uygulamanın belirlenmesi amaçlanmıştır. Toplam 199 kişinin katıldığı bu çalışma sonuçları yayın olarak
hazırlanıp yakın zamanda Genome Biology dergisine sunulmuştur.
4. Partners in Excellence Ekip Ödülü (12/2011)
Laboratory for Molecular Medicine, Partners HealthCare Center for Personalized Genetic Medicine.
Ekip ödülü: PanCardio Next Gen sekanslama test panelinin 54 kardiyomyopati geni için kullanıma
sunumu
5. Poster Ödülü (Birincilik ödülü) (Ekim 2010)
VI. Uluslararası Hematolojik Kanserler Konferansı
6. Poster Ödülü (Üçüncülük ödülü; Genomics, Proteomics ve Imaging kategorisinde) (Ekim 2010)
UT MD Anderson Kanser Merkezi Kanser Araştırma Sempozyumu 2010
7. Poster Ödülü (Birincilik) (Mart 2003)
Teksas Universitesi Biyomedikal Bilimler Fakültesi, İnsan ve Moleküler Genetik Program Sempozyumu
10. Araştırma Destekleri:
TUBITAK 2232-Yurda Dönüş Araştırma Destek Programı; Proje Yürütücüsü (03/ 2014-02/ 2016)