Timuçin AVŞAR

Timuçin AVŞAR (PhD) (July 2015)
CURRICULUM VITAE
1. Name Surname : Timuçin AVŞAR
Address
: Göktürk mah. Istanbul Cad. Telekom Sok. Arcadium 1 No:18 Eyüp
İstanbul
Phone
E-Mail
: 0533 731 4937
: [email protected]
2. Date of Birth
: 30.05.1986
3. Title
: Molecular Biologist and Geneticist
4.Öğrenim Durumu :
Degree
Bachelor
Bachelor
(Erasmus)
Graduate (Masters
Degree)
Graduate (PhD)
Programme
Molecular Biology and
Genetics
Moleculare
Biotechnologie
Molecular Biology,
Genetics and
Biotechnology
Molecular Biology,
Genetics and
Biotechnology
University
Technische Universitaet
Muenchen
Year
2003 2007
2005 2006
İstanbul Technical University
2007 2009
İstanbul Technical University
2009 2013
İstanbul Technical University
5. Academic Titles
Molecular Biologist and Geneticist (PhD)
Molecular Neuroscientist
6. Yönetilen Yüksek Lisans ve Doktora Tezleri
6.1. Master Thesis
İstanbul Technical University – Institute of Life Sciences
Thesis Title: “Protein Biomarkers Of Multiple Sclerosis; Studies Of Cerebrospinal Fluids From
Clinically Different Subtypes of Multiple Sclerosis Patients”
6.2. PhD Thesis
İstanbul Technical University – Institute of Life Sciences
Thesis Title: “Investigation of Molecular Pathways and Biomarkers in Multiple Sclerosis Clinical
Subtypes”
7. Publications
7.1. Internationally reviewed and indexed journal articles
1. Avsar, T., Korkmaz, D., Tütüncü, M., Demirci, N. O., Saip, S., Kamasak, M., Siva A. & Turanli,
E. T. (2012). Protein biomarkers for multiple sclerosis: semi-quantitative analysis of
cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis. Multiple
Sclerosis Journal, 18(8), 1081-1091.
2. Yener, U., Avsar, T., Akgün, E., Şeker, A., Bayri, Y., & Kılıç, T. (2012). Assessment of
antiangiogenic effect of imatinib mesylate on vestibular schwannoma tumors using in vivo
corneal angiogenesis assay: Laboratory investigation. Journal of neurosurgery, 117(4), 697704.
3. Özkan, A., Biçer, A., Avşar, T., Şeker, A., Toktaş, Z. O., Bozkurt, S. U. & Kılıç, T. (2012).
Temporal expression analysis of angiogenesis-related genes in brain development. Vascular
cell, 4(1), 1-9.
4. Karal-Yilmaz, O., Ozkan, A., Akgun, E., Kukut, M., Baysal, K., Avsar, T., & Kilic, T. (2013).
Controlled release of imatinib mesylate from PLGA microspheres inhibit craniopharyngioma
mediated angiogenesis. Journal of Materials Science: Materials in Medicine, 24(1), 147-153.
5. Clark, V. E., Erson-Omay, E. Z., Serin, A., Yin, J., Cotney, J., Özduman, K., Avsar T et. al. &
Günel, M. (2013). Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7,
KLF4, AKT1, and SMO. Science, 339(6123), 1077-1080.
6. Yener, U., Avsar, T., Akgun, E., Seker, A., Bayri, Y., & Kilic, T. (2013). Angiogenesis
RESPONSE. Journal of Neurosurgery, 119(5), 1353-1353.
7. Kılıç, K., Avsar, T., Akgün, E., Özkan, A., Toktaş, Z. O., Şeker, A., & Kılıç, T. (2013). Gamma
Knife Radiosurgery Inhibits Angiogenesis of Meningiomas: In Vivo Rat Corneal Assay. World
neurosurgery, 80(5), 598-604.
8. Villar, L. M., Casanova, B., Ouamara, N., Comabella, M., Jalili, F., Leppert, D., Avsar T. &
Bar‐ Or, A. (2014). Immunoglobulin M oligoclonal bands: Biomarker of targetable inflammation in
primary progressive multiple sclerosis. Annals of neurology, 76(2), 231-240.
9. Ceylan, D., Tatarlı, N., Avsar, T., Arslanhan, A., Bozkurt, S. U., Bağcı, P., & Kilic, T. (2014). In
vivo effect of pregnancy on angiogenesis potential of arteriovenous malformation tissue samples:
an experimental study. Journal of neurosurgical sciences.
10. Kuhle, J., Disanto, G., Dobson, R., Adiutori, R., Bianchi, L., Topping, J., Avsar T et. al. &
Martínez, A. D. (2015). Conversion from clinically isolated syndrome to multiple sclerosis: a large
multicentre study. Multiple Sclerosis Journal, 1352458514568827.
11. Avsar, T., Durası, İ. M., Uygunoğlu, U., Tütüncü, M., Demirci, N. O., Saip, S., Siva A &
Turanlı, E. T. (2015). CSF Proteomics Identifies Specific and Shared Pathways for Multiple
Sclerosis Clinical Subtypes. PLoS ONE. e0122045.
12. Atabay, K. D., Yildiz, M. T., Avsar, T., Karabay, A., & Kiliç, T. (2015). Knockdown of Pin1
leads to reduced angiogenic potential and tumorigenicity in glioblastoma cells. Oncology
Letters. Online publication.
7.2. Publications in Proceedings and International Congress Abstract Books
1. Avsar, T., Yener, U., & Akgun, E. (2011). Abstract A30: Investigation of imatinib mesylate
effect on vestibular schwannoma tumor by using in vivo corneal angiogenesis model. Cancer
Prevention Research, 4(10 Supplement), A30-A30.
2. Avsar, T., Atabay, K. D., Mehmet, Y. T., Kilic, T., & Karabay, A. K. (2011). Abstract A31:
Effects of Pin1 inhibition on tumorigenicity of glioblastoma multiforme. Cancer Prevention
Research, 4(10 Supplement), A31-A31.
3. Avsar, T., Akgun, E., Yılmaz, O. K., Küküt, M., Baysal, K., Bayir, Y., ... & Kilic, T. (2011).
Abstract B48: Inhibition of recurrence of craniopharyngiomas with imatinib mesylate-loaded poly
(lactide-co-glycolide)(PLGA) microspheres. Cancer Prevention Research, 4(10 Supplement),
B48-B48.
4. Ayranci, G., Avsar, T., Seker, A., Kilic, T., & Bozkurt, S. (2012). Leptin and leptin receptor
expression in pituitary adenomas. In VIRCHOWS ARCHIV (Vol. 461, pp. S81-S82). 233 Sprıng
St, New York, Ny 10013 USA: Springer.
5. Avsar, T., Uygunoglu, U., Tutuncu, M., Demirci, N. O., Saip, S., Siva, A., & Turanli, E. T.
(2012, October). Proteomic analysis: identification of candidate protein biomarkers in the CSF
and serum samples of patients with clinically different multiple sclerosis subtypes. In Multiple
Sclerosis Journal (Vol. 18, pp. 263-264). 1 Olıvers Yard, 55 Cıty Road, London Ec1y 1sp,
England: Sage Publications Ltd.
6. Avsar T, Uygunoğlu U, Tütüncü M, Demirci NO, Saip S, Siva A and Turanlı ET, (2012).
Proteomic Analysis: Identification of candidate protein biomarkers in the CSF and serum
samples of patients with clinically different multiple sclerosis subtypes. 28th Congress of the
European Comittee For Treatment and Research in Multiple Sclerosis (ECTRIMS), 10 –
14.10. Lyon, France, Poster Presentation
7. Avsar T, Durası IM, Saip S, O. OU, Siva A and Turanlı ET, (2012) Disease Specific Pathway
Analysis in Multiple Sclerosis. American Society of Human Genetics, Annual Meeting, 610.11., San Francisco, USA, Poster Prensentation
8. Avşar T, Terzioğlu G, Çelikyapı G, Bozkurt SU, Demirel GY, Siva A, Altuğ T and Turanlı ET.
(2012) CXCR4 (Chemokine Receptor) Expression Analysis In Chronic Cuprizone Model of
Multiple Sclerosis By Quantitative Real Time PCR. American Society of Human Genetics,
Annual Meeting, 6-10.11.2012, San Francisco, USA, Poster Prensentation
9. Kuhle, J., Dobson, R., Bestwick, J. P., Topping, J., Dalla Costa, G., Khademi, M., Avsar T. &
Brassat, D. (2013, October). Multivariate clinically isolated syndrome (CIS) risk factor study:
towards individual prognosis and treatment indication in CIS. In Multiple Sclerosis Journal
(Vol. 19, No. 11, pp. 33-34). 1 Olivers Yard, 55 City Road, London Ec1y 1sp, England: Sage
Publications Ltd.
10. Avsar, T., Durasi, İ., Uygunoglu, U., Tutuncu, M., Demirci, N., Saipoglu, S., ... & Turanli, E.
(2015). Proteomic Analysis in CSF Identified Subtype Specific and Shared Molecular Pathways
for Multiple Sclerosis Clinical Phenotypes (P5. 216). Neurology, 84(14 Supplement), P5-216.
7.3. Book Chapters
1. Eda Tahir Turanli, Timucin Avsar, Uğur Uygunoğlu, Orhun H. Kantarci, Aksel Siva. (2015).
General Methods in Biomarker Research and their Applications, Biomarkers for Phase
Switches in Multiple Sclerosis, ISBN: 978-94-007-7695-1.
2. Timuçin Avşar, Uğur Uygunoğlu Aksel Siva ve Eda Tahir Turanlı, (2013) Temel ve Klinik
Nöroimmunoloji, Multipl Sklerozda Biyobelirteçlerin Tanı ve Prognozdaki Önemi, ISBN:
3872003, 2013
7.4. National Peer Reviewed Publications
7.5. National Scientific Meeting Abstracts
1. Avşar T, Turanli E, Pusuluk O, Yanikkaya GD, Saip S, Altıntaş A, Sav A, Siva A,
Establishment of Multiple Sclerosis Cuprizone Mouse Model. IX. International Attended,
National Medical Biology and Genetics Congress. 23-27 October, 2007, Antalya, Turkey,
Poster Presentation.
2. Avşar T, Turanli ET, Tütüncü M, Siva A; Protein Biomarkers for Multiple Sclerosis: Analysis of
cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis X.
National Medical Biology and Genetics Congress, 28 – 31 October 2009: Bodrum, Muğla,
Turkey, Poster presentation.
3. Genç A, Avşar T, Bozkurt SU, Karabağlı P, Şeker A, Bayri Y, Konya D, Kılıç T, The
importance of Gamma Knife Radiosurgery in the treatment of Central Neurocytomas. Nervous
System Surgery Society VI. Scientific Congress, 28-31 Ekim 2010, Marmaris Muğla, Turkey,
Poster presentation.
4. Tural S, Avşar T, Bozkurt SU, Şeker A, Bayri Y, Konya D, Özek M, Kılıç T, The importance of
Gamma Knife Radiosurgery in the treatment of optic gliomas. Nervous System Surgery
Society VI. Scientific Congress, 28-31 Ekim 2010, Marmaris Muğla, Turkey, Poster
presentation
5. Yilmaz OK, Ozkan A, Akgun E, Kukut M, Baysal K, Avşar T, Kilic T, Inhibition of Recurrence
of Craniopharyngiomas with Imatinib Mesylate-Loaded Poly(Lactide-Co-Glycolide) (PLGA)
Microspheres. Turkish Neurosurgery Society, 25. Scientific Congress, 22-26 April Belek ,
Antalya, Turkey 2011, Poster Presetation.
6. Kılıç K, Akgün E, Avşar T, Özkan A, Toktaş ZO, Şeker A, Bayri Y, Konya D, Kılıç T, GammaKnife Radiosurgery Inhibits Meningioma Induced Angiogenesis: Dose Escalation by Corneal
Angiogenesis. Turkish Neurosurgery Society, 25. Scientific Congress, 22-26 April Belek ,
Antalya, Turkey 2011, Oral Presetation.
7. Yener U, Avşar T, Bozkurt SU, Şeker A, Bayri Y, Konya D, Özek M, Kılıç T, Investigation Of
Imatinib Mesylate Effect On Vestibular Schwannoma Tumor By Using In Vivo Corneal
Angiogenesis Model. Turkish Neurosurgery Society, 25. Scientific Congress, 22-26 April
Belek , Antalya, Turkey 2011, Oral Presetation.
8. Avsar T, Uygunoğlu U, Tütüncü M, Demirci ON, Saip S, Siva A, Turanli ET, (2012) Proteom
study in clinically different subtypes of multiple sclerosis, by using CSF and Serum samples:
Subtype specific protein biomarker identification. National Neurology Congress, Antalya,
Turkey, Oral Presentation
7.6 Other Publications
1. Avsar T, Siva A, Altug T and Turanli ET, (2011) Neuro-Degeneration and Inflammation Based
Animal Models of Multiple Sclerosis, Turkish Immunology Journal.
2. Avsar T, Tütüncü M, Demirci NO, Saip S, Siva A and Turanlı ET, ‘Proteomic Analysis In The
CSF and Serum Pool of Clinically Different Multiple Sclerosis Patients’, Turkey Clinical Medical
Sciences Journal Supplement [Türkiye Klinik Tıp Bilimleri Dergisi], December 2011, Vol:31 No:6,
p:173.
3. Avsar T, Bozkurt SU, Demirel GY, Saip S, Altıntaş A, Siva A, Altuğ T and Turanli ET, (2011).
Investigation of Neuro-Inflammatory Parameters in the Cuprizone Mouse Model of Multiple
Sclerosis, Turkey Clinical Medical Sciences Journal Supplement [Türkiye Klinik Tıp
Bilimleri Dergisi], December 2011, Vol:31 No:6, p:173-174.
4. Terzioğlu G, Avsar T, Çakan G, Çelikyapı G, Bozkurt SU, Demirel GY, Siva A, Altuğ T and
Turanli ET, (2011). Investigation of CXCR4 (Chemokıne Receptor) Gene Level In The Chronic
Cuprizone Model By Quantitative Real Time PCR, Turkey Clinical Medical Sciences Journal
Supplement [Türkiye Klinik Tıp Bilimleri Dergisi], December 2011, Vol:31 No:6, p:186.
5. Avsar T, Korkmaz D, Kamasak M, Siva A, Turanli ET, Analysis of Tau, MBP, MOG, NFL and
GFAP protein from cerebrospinal fluids of clinically different multiple sclerosis patients using
computational classification methods. In VIVO International Journal of Experimental and
Clinical Pathophysiology and Drug Research, Vol:25, No: 3 pp.367-576 May – June 201, p 5.
8.Projects
1. TÜBİTAK – SBAG (2008 – 2009): Oral Liken Planus İmmunopatogenezinde Th1/Th2 Sitokin
Profili, Sitotoksik T-Hücre Aktivasyonu ve Hücre Aktivasyonunda Rolü Olan Adezyon Molekülleri
Ile Kemokin Reseptörlerinin Periferik Kan ve Doku Örneklerinde Değerlendirilmesi, - Researcher
(Budget: 22691 TL)
2. TÜBİTAK – SBAG – 109S070 (2010 – 2013): Multipl Skleroz'da Proteomik Analizler: Farklı
MS Klinik Alt Tiplerinin BOS ve Serum Örneklerinde Protein Belirteçlerinin Tanımlanması –
Bursiyer (Budget: 307038 TL)
3. Tarımsal Araştımalar Genel Müdürlüğü (TAGEM) – (2013 – 2014) Süt ve Süt Ürünlerinde
Sitokrom B Primerleri ile Tağşiş Tespitine Yönelik Kantitatif Polimeraz Zincir Reaksiyonu Kiti
Geliştirilmesi – Project Manager (Budget: 27758 TL)
4. Sanayi ve Ticaret Bakanlığı TEKNOGİRİŞİM Projesi – (2013 – 2014) Multipl Skleroz
Hastalığının Tanı ve Prognozunda Önemli Biyobelirteçlerin Kantitatif Analizlerine Yönelik Elisa
Kiti Geliştirilmesi – Project Manager (Budget: 99850 TL)
5. TÜBİTAK – TEYDEB – 9130074 (2014 – 2016) Hipertrofik Kardiyomyopati İle İlgili
Mutasyonların Tespitine Yönelik Genetik Tarama Kiti Geliştirilmesi – Project Manager (Budget:
623351 TL)
6. TÜBİTAK – TEYDEB – 9130074 (2014 – 2016) Yaygin Kalıtsal Hastalıklarının Taşıyıcılık
Tespitine Yönelik Mutasyon Tarama Kiti Geliştirilmesi – Project Manager (Budget: 713076 TL)
7. TÜBİTAK – TEYDEB – 9130074 (2014 – 2016) Kalitsal Periyodik Ateş Hastalıklarının Tespiti
İçin Genetik Tanı Kiti Geliştirilmesi – Project Manager
9. Awards
1. Ulusal Nöroloji Kongresi (2015), En İyi Sözel Poster Bildirisi 2.’lik Ödülü
2. Türk Nöroşirurji Derneği 29. Bilimsel Kongresi, En iyi Sözel Poster Bildirisi 1.’lik ödülü